The three main stumbling blocks for anticancer T cells.

Details

Serval ID
serval:BIB_F11BF21971E8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The three main stumbling blocks for anticancer T cells.
Journal
Trends in Immunology
Author(s)
Baitsch L., Fuertes-Marraco S.A., Legat A., Meyer C., Speiser D.E.
ISSN
1471-4981 (Electronic)
ISSN-L
1471-4906
Publication state
Published
Issued date
2012
Volume
33
Number
7
Pages
364-372
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
Memory and effector T cells have the potential to counteract cancer progression, but often fail to control the disease, essentially because of three main stumbling blocks. First, clonal deletion leads to relatively low numbers or low-to-intermediate T cell receptor (TCR) affinity of self/tumor-specific T cells. Second, the poor innate immune stimulation by solid tumors is responsible for inefficient priming and boosting. Third, T cells are suppressed in the tumor microenvironment by inhibitory signals from other immune cells, stroma and tumor cells, which induces T cell exhaustion, as demonstrated in metastases of melanoma patients. State-of-the-art adoptive cell transfer and active immunotherapy can partially overcome the three stumbling blocks. The reversibility of T cell exhaustion and novel molecular insights provide the basis for further improvements of clinical immunotherapy.
Keywords
Animals, Autoimmunity, Disease Progression, Humans, Immunotherapy, Neoplasms/immunology, Neoplasms/pathology, Signal Transduction, T-Lymphocytes/immunology, T-Lymphocytes/metabolism
Pubmed
Web of science
Create date
22/11/2012 14:22
Last modification date
20/08/2019 16:18
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