Interleukin 10 inhibits inflammatory cells infiltration in endotoxin-induced uveitis

Détails

ID Serval
serval:BIB_F11591C7C5D6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Interleukin 10 inhibits inflammatory cells infiltration in endotoxin-induced uveitis
Périodique
Graefe's Archive for Clinical and Experimental Ophthalmology
Auteur(s)
Hayashi  S., Guex-Crosier  Y., Delvaux  A., Velu  T., Roberge  F. G.
ISSN
0721-832X (Print)
Statut éditorial
Publié
Date de publication
10/1996
Volume
234
Numéro
10
Pages
633-6
Notes
Comparative Study
Journal Article --- Old month value: Oct
Résumé
BACKGROUND: Endotoxin-induced uveitis (EIU) is a model for acute anterior uveitis associated with a variety of pro-inflammatory cytokines and nitric oxide production. Interleukin 10 (IL-10) down-regulates these inflammatory mediators. We report a study of the effect of systemic administration of IL-10 on the inflammatory parameters of EIU. METHODS: Uveitis was induced in C3H/HeN mice by subcutaneous injection of 200 micrograms lipopolysaccharide (LPS) per mouse. Intraocular inflammation was assessed by leukocyte count and measurement of the protein concentration in the aqueous humor (AH). Mouse recombinant IL-10 at 1000 U or its vehicle alone were administered by three intravenous injections given 4.0 h and 0.5 h before and 8.0 h after LPS injection. RESULTS: The inflammatory cell infiltration in the eyes was significantly reduced in four of five experiments from 40% to 64% in the groups treated with IL-10 compared to the control groups (P < 0.05). In contrast, the level of protein exudation in the anterior chamber (AC) was not significantly affected by IL-10 treatment. CONCLUSION: IL-10 reduces the cellular infiltration in the ocular inflammation produced by endotoxin. This result suggests potential usefulness for IL-10 in the treatment of severe anterior uveitis with a strong cellular component.
Mots-clé
Animals Chemotaxis, Leukocyte/*drug effects Female Infusions, Intravenous Interleukin-10/*pharmacology *Lipopolysaccharides Macrophages/*drug effects/physiology Mice Mice, Inbred C3H Neutrophils/*drug effects/physiology *Salmonella typhimurium Uveitis, Anterior/chemically induced/*drug therapy/physiopathology
Pubmed
Web of science
Création de la notice
28/01/2008 13:45
Dernière modification de la notice
03/03/2018 22:37
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