Structure function relationships of ENaC and its role in sodium handling.

Détails

ID Serval
serval:BIB_F0D8C5ACB7A0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Structure function relationships of ENaC and its role in sodium handling.
Périodique
Advances in Experimental Medicine and Biology
Auteur(s)
Schild L., Kellenberger S.
ISSN
0065-2598[print], 0065-2598[linking]
Statut éditorial
Publié
Date de publication
2001
Volume
502
Pages
305-314
Langue
anglais
Résumé
The epithelial sodium channel (ENaC) in the apical membrane of polarized epithelial cells is the rate-limiting step for Na entry into the cell; in series with the basolateral Na pump, it allows the vectorial transepithelial transport of Na ions. ENaC is expressed in different epithelia like the distal nephron or colon, and the airways epithelium. In the lung ENaC controls the composition and the amount of pulmonary fluid, whereas in the distal nephron ENaC under the control of aldosterone and vasopressin, is essential to adapt the amount of Na+ reabsorbed with the daily sodium intake. Activating mutations of ENaC cause severe disturbances of Na+ homeostasis leading to hypertension in human and in mouse models. Functional expression of ENaC in different cell systems allowed the identification of structural domains of the protein that are essential for channel function and/or modulation of channel activity. Site-directed mutations in specific domains of the channel protein lead to channel hyperactivity or channel loss of function. Knowledge about ENaC structure-function relationships opens new opportunities for development of pharmacological tools for controlling ENaC activity, such as channel activators of potential benefit in the treatment of pulmonary edema, or highly potent ENaC blockers with natriuretic effects.
Mots-clé
Animals, Epithelial Sodium Channel, Humans, Sodium/metabolism, Sodium Channels/genetics, Sodium Channels/metabolism, Structure-Activity Relationship
Pubmed
Web of science
Création de la notice
24/01/2008 13:45
Dernière modification de la notice
20/08/2019 17:18
Données d'usage