Endocarditis due to gram-negative bacilli at a French teaching hospital over a 6-year period: clinical characteristics and outcome.

Details

Serval ID
serval:BIB_F094A02628DF
Type
Article: article from journal or magazin.
Collection
Publications
Title
Endocarditis due to gram-negative bacilli at a French teaching hospital over a 6-year period: clinical characteristics and outcome.
Journal
Infectious diseases
Author(s)
Loubet P., Lescure F.X., Lepage L., Kirsch M., Armand-Lefevre L., Bouadma L., Lariven S., Duval X., Yazdanpanah Y., Joly V.
ISSN
2374-4243 (Electronic)
ISSN-L
2374-4243
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
47
Number
12
Pages
889-895
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Infective endocarditis (IE) due to gram-negative bacilli (GNB) is rare. However, several studies described a change in the epidemiological profile of patients within the past few years.
We reviewed all cases diagnosed and followed in the infectious diseases ward of a French teaching hospital in Paris between 2009 and 2014, inclusive.
Among the 17 patients with definite GNB-IE (11 male, mean age 54 years), 12 (70%) were due to non-HACEK GNB and 5 (30%) to HACEK group GNB. A prosthetic valve was involved in 10 cases (8 in non-HACEK and 2 in HACEK group). Escherichia coli (4/12 patients) and Pseudomonas aeruginosa (3/12 patients) were the most common pathogens in the first group; all the pathogens in the second group were Haemophilus spp. One-third of the patients with non-HACEK GNB had nosocomial IE, whereas injection drug use-related infections were rare (2/12). All patients with HACEK infection had at least one complication (intracardiac abscess, stroke or other systemic embolization). All patients were treated by antibiotic combination therapy during a median time of 42 days (interquartile range (IQR) = 42-42) and 10 (59%) underwent cardiac surgery. One death at 9 months was observed in the non-HACEK group.
Regarding HACEK IE, this report supports the frequent association with vascular complications. Regarding non-HACEK GNB IE, this report supports the increasing proportion of nosocomial infections. We reported a high proportion of surgery in the therapeutic management of both HACEK and non-HACEK groups associated with no in-hospital mortality.
Keywords
Abscess/microbiology, Aged, Anti-Bacterial Agents/therapeutic use, Cardiac Surgical Procedures/adverse effects, Cross Infection/drug therapy, Cross Infection/epidemiology, Cross Infection/microbiology, Drug Therapy, Combination, Endocarditis, Bacterial/drug therapy, Endocarditis, Bacterial/epidemiology, Endocarditis, Bacterial/microbiology, Escherichia coli/isolation & purification, Female, Gram-Negative Bacteria/classification, Gram-Negative Bacteria/isolation & purification, Gram-Negative Bacterial Infections/drug therapy, Gram-Negative Bacterial Infections/epidemiology, Gram-Negative Bacterial Infections/microbiology, Haemophilus/isolation & purification, Hospital Mortality, Hospitals, Teaching, Humans, Male, Middle Aged, Paris/epidemiology, Pseudomonas aeruginosa/isolation & purification, Time Factors, Treatment Outcome, Endocarditis, Enterobacteriaceae, HACEK, gram-negative bacilli, non-HACEK
Pubmed
Web of science
Create date
28/03/2019 17:32
Last modification date
20/08/2019 16:18
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