Monoclonal antibodies to gamma-interferon treated LAN-1 cells detect modulation of ganglioside GD2 exposure on human neuroblastoma cells

Détails

ID Serval
serval:BIB_F08B63CC6842
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Monoclonal antibodies to gamma-interferon treated LAN-1 cells detect modulation of ganglioside GD2 exposure on human neuroblastoma cells
Périodique
Anticancer Research
Auteur(s)
Gross  N., Beck  D., Portoukalian  J., Carrel  S., Favre  S.
ISSN
0250-7005
Statut éditorial
Publié
Date de publication
12/1989
Peer-reviewed
Oui
Volume
9
Numéro
6
Pages
1519-24
Notes
Journal Article --- Old month value: Nov-Dec
Résumé
A panel of 8 new Mabs have been produced against neuroblastoma cells (LAN-1) previously treated with IFN-gamma. All selected Mabs from 2 different fusions have been shown to detect epitopes on the GD2 ganglioside molecules highly expressed on all cells of neural crest origin including neuroblastoma, glioblastoma and melanoma. Our results imply that modulation of GD2 exposure on NB cells is dependent on culture conditions and moreover that IFN-gamma increases the surface expression of GD2 and thereby enhances their immunogenicity.
Mots-clé
Antibodies, Monoclonal/*diagnostic use Antigens, Neoplasm/analysis Cell Line Gangliosides/*metabolism Humans Immunohistochemistry Interferon-gamma, Recombinant/*pharmacology Neuroblastoma Tumor Cells, Cultured/cytology/drug effects/*metabolism
Pubmed
Web of science
Création de la notice
20/01/2008 16:56
Dernière modification de la notice
03/03/2018 22:36
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