Altered catecholamine receptor affinity in rabbit aortic intimal hyperplasia.

Détails

ID Serval
serval:BIB_F06CD877ADDE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Altered catecholamine receptor affinity in rabbit aortic intimal hyperplasia.
Périodique
Journal of Surgical Research
Auteur(s)
O'Malley M.K., Cotecchia S., Hagen P.O.
ISSN
0022-4804 (Print)
ISSN-L
0022-4804
Statut éditorial
Publié
Date de publication
1991
Volume
51
Numéro
2
Pages
148-153
Langue
anglais
Résumé
Intimal thickening is a universal response to endothelial denudation and is also thought to be a precursor of atherosclerosis. We have demonstrated selective supersensitivity in arterial intimal hyperplasia to norepinephrine and we now report a possible mechanism for this. Binding studies in rabbit aorta with the selective alpha 1-adrenergic radioligand 125I-HEAT demonstrated that there was no change in receptor density (20 +/- 4 fmole/10(6) cells) in intact vascular smooth muscle cells at either 5 or 14 days after denudation. However, competition studies showed a 2.6-fold increase in alpha 1-adrenergic receptor affinity for norepinephrine in intimal hyperplastic tissue (P less than 0.05). This increased affinity for norepinephrine was associated with a greater increase in 32P-labeled phosphatidylinositol (148% intimal thickening versus 76% control) and phosphatidic acid (151% intimal thickening versus 56% control) following norepinephrine stimulation of free floating rings of intimal hyperplastic aorta. These data suggest that the catecholamine supersensitivity in rabbit aortic intimal hyperplasia is receptor mediated and may be linked to the phosphatidylinositol cycle.
Mots-clé
Animals, Aorta/metabolism, Aorta/pathology, Cell Membrane/metabolism, Hyperplasia, Muscle, Smooth, Vascular/cytology, Muscle, Smooth, Vascular/metabolism, Norepinephrine/metabolism, Phospholipids/metabolism, Phosphorus Radioisotopes/diagnostic use, Rabbits, Receptors, Adrenergic/metabolism, Receptors, Adrenergic, alpha/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 16:18
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