Bereit fur neue medizinische Herausforderungen--die "Genetics HIV Cohort" der Schweizerischen HIV Kohortenstudie. [The genetics HIV cohort of the Swiss HIV Cohort Study--facing the new challenges in medicine]

Détails

ID Serval
serval:BIB_F0655016C364
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Bereit fur neue medizinische Herausforderungen--die "Genetics HIV Cohort" der Schweizerischen HIV Kohortenstudie. [The genetics HIV cohort of the Swiss HIV Cohort Study--facing the new challenges in medicine]
Périodique
Therapeutische Umschau
Auteur(s)
Telenti  A., Furrer  H.
ISSN
0040-5930 (Print)
Statut éditorial
Publié
Date de publication
10/2004
Volume
61
Numéro
10
Pages
613-8
Notes
Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
Host genetic factors determine the individual natural course of HIV infection and influence the response to therapy and the occurrence of adverse events to treatment. Variants of multiple genes are associated with faster but also slower development of severe immunodeficiency. However, only very rarely the variant of one single gene explains a specific clinical phenotype. But multiple genetic marker form a complex trait, which is difficult to analyse biostatistically. Research in this rapidly evolving field asks for structures in which hypotheses can be generated and evaluated and which combine basic and diagnostic and therapeutic research. The large amount of prospective information on HIV disease natural history and treatment response of the Swiss HIV Cohort Study will make of the Genetics project an excellent test-setting for some of the immediate difficulties in this research field: validation of new markers and modelling of complex traits.
Mots-clé
Anti-HIV Agents/administration & dosage/adverse effects/therapeutic use Anti-Retroviral Agents/administration & dosage/adverse effects/therapeutic use Biomedical Research CD4 Lymphocyte Count Cohort Studies Disease Progression Genetic Markers Genetic Research HIV Infections/drug therapy/*epidemiology/*genetics Humans Phenotype Switzerland/epidemiology Time Factors
Pubmed
Création de la notice
25/01/2008 15:46
Dernière modification de la notice
03/03/2018 22:36
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