Eosinophilic esophagitis: current perspectives from diagnosis to management.

Détails

ID Serval
serval:BIB_F0594657DDD8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Eosinophilic esophagitis: current perspectives from diagnosis to management.
Périodique
Annals of the New York Academy of Sciences
Auteur(s)
Moawad F.J., Cheng E., Schoepfer A., Al-Haddad S., Bellizzi A.M., Dawson H., El-Zimaity H., Guindi M., Penagini R., Safrooneva E., Chehade M.
ISSN
1749-6632 (Electronic)
ISSN-L
0077-8923
Statut éditorial
Publié
Date de publication
09/2016
Peer-reviewed
Oui
Volume
1380
Numéro
1
Pages
204-217
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Eosinophilic esophagitis (EoE) is a chronic antigen-mediated immune disease of the esophagus characterized by symptoms related to esophageal dysfunction, as well as significant esophageal eosinophilia. Although dense eosinophilia is the hallmark of EoE, other characteristic histologic features have been described that may help distinguish EoE from other competing diagnoses, although none are specific to EoE. One or more foods and, at times, environmental allergens trigger EoE. Left untreated, esophageal inflammation in EoE may lead to esophageal remodeling and stricture formation. Symptoms in EoE vary with age, as they relate to the progression of the disease from an inflammatory to a fibrostenotic phenotype over time. There are currently no U.S. Food and Drug Administration-approved therapies for EoE. Current options include various dietary-restriction therapies, topical corticosteroids, and esophageal dilations. Several emerging therapies aiming at restoring the esophageal barrier function or targeting various inflammatory cells or their mediators are under investigation.

Mots-clé
Disease Management, Disease Progression, Endoscopy/methods, Eosinophilic Esophagitis/diagnosis, Eosinophilic Esophagitis/therapy, Glucocorticoids/therapeutic use, Humans, Proton Pump Inhibitors/therapeutic use, allergy, corticosteroids, dietary treatment, dilation, dysphagia, eosinophilia, eosinophilic esophagitis, esophagitis
Pubmed
Web of science
Création de la notice
05/08/2016 17:59
Dernière modification de la notice
03/03/2018 22:36
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