Endothelial Cell Responses to Biomechanical Forces in Lymphatic Vessels.

Détails

ID Serval
serval:BIB_F058954BCABC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Endothelial Cell Responses to Biomechanical Forces in Lymphatic Vessels.
Périodique
Antioxidants & redox signaling
Auteur(s)
Sabine A., Saygili Demir C., Petrova T.V.
ISSN
1557-7716 (Electronic)
ISSN-L
1523-0864
Statut éditorial
Publié
Date de publication
01/09/2016
Peer-reviewed
Oui
Volume
25
Numéro
7
Pages
451-465
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Lymphatic vessels are important components of the cardiovascular and immune systems. They contribute both to the maintenance of normal homeostasis and to many pathological conditions, such as cancer and inflammation. The lymphatic vasculature is subjected to a variety of biomechanical forces, including fluid shear stress and vessel circumferential stretch.
This review will discuss recent advances in our understanding of biomechanical forces in lymphatic vessels and their role in mammalian lymphatic vascular development and function.
We will highlight the importance of fluid shear stress generated by lymph flow in organizing the lymphatic vascular network. We will also describe how mutations in mechanosensitive genes lead to lymphatic vascular dysfunction.
Better understanding of how biomechanical and biochemical stimuli are perceived and interpreted by lymphatic endothelial cells is important for targeting regulation of lymphatic function in health and disease. Important remaining critical issues and future directions in the field will be discussed in this review. Antioxid. Redox Signal. 25, 451-465.

Mots-clé
Animals, Disease Susceptibility, Endothelial Cells/physiology, Humans, Lymphangiogenesis, Lymphatic Vessels/cytology, Lymphatic Vessels/physiology, Mammals, Mechanotransduction, Cellular, Shear Strength, Stress, Mechanical
Pubmed
Web of science
Création de la notice
05/09/2017 18:25
Dernière modification de la notice
03/03/2018 22:36
Données d'usage