Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice.

Détails

ID Serval
serval:BIB_F01F8E2F0506
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice.
Périodique
European Journal of Immunology
Auteur(s)
Maillard I., Launois P., Himmelrich H., Acha-Orbea H., Diggelmann H., Locksley R.M., Louis J.A.
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
2001
Volume
31
Numéro
4
Pages
1288-1296
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
Early production of IL-4 by LACK-reactive Vbeta4-Valpha8 CD4(+) T cells instructs aberrant Th2 cell development and susceptibility to Leishmania major in BALB / c mice. This was demonstrated using Vbeta4(+)-deficient BALB / c mice as a result of chronic infection with MMTV (SIM), a mouse mammary tumor virus expressing a Vbeta4-specific superantigen. The early IL-4 response was absent in these mice which develop a Th1 response to L. major. Here, we studied the functional plasticity of LACK-reactive Vbeta4-Valpha8 CD4(+) T cells using BALB/ c mice inoculated with L. major shortly after infection with MMTV (SIM), i. e. before deletion of Vbeta4(+) cells. These mice fail to produce the early IL-4 response to L. major and instead exhibit an IFN-gamma response that occurs within LACK-reactive Vbeta4-Valpha8 CD4(+) T cells. Neutralization of IFN-gamma restores the production of IL-4 by these cells. These data suggest that the functional properties of LACK-reactive Vbeta4-Valpha8 CD4(+) T cells are not irreversibly fixed.
Mots-clé
Animals, Antibodies/immunology, Antibodies/pharmacology, Antigens, Protozoan, Cell Differentiation/drug effects, Complementarity Determining Regions/immunology, Female, Interferon-gamma/antagonists & inhibitors, Interferon-gamma/genetics, Interleukin-4/biosynthesis, Interleukin-4/genetics, Leishmania major/growth & development, Leishmania major/immunology, Leishmaniasis, Cutaneous/immunology, Leishmaniasis, Cutaneous/parasitology, Lymphocyte Activation/drug effects, Lymphocyte Count, Mammary Tumor Virus, Mouse/genetics, Mice, Mice, Inbred BALB C, Protozoan Proteins/immunology, RNA, Messenger/genetics, RNA, Messenger/metabolism, Superantigens/genetics, Superantigens/immunology, Th2 Cells/cytology, Th2 Cells/drug effects, Time Factors, Transduction, Genetic, Up-Regulation
Pubmed
Web of science
Création de la notice
24/01/2008 15:47
Dernière modification de la notice
03/03/2018 22:36
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