Steroid hormone regulation of C. elegans and Drosophila aging and life history.

Détails

ID Serval
serval:BIB_F01EE982AA8C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Steroid hormone regulation of C. elegans and Drosophila aging and life history.
Périodique
Experimental Gerontology
Auteur(s)
Gáliková M., Klepsatel P., Senti G., Flatt T.
ISSN
1873-6815 (Electronic)
ISSN-L
0531-5565
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
46
Numéro
2-3
Pages
141-147
Langue
anglais
Résumé
In the last two decades it has become clear that hormones and gene mutations in endocrine signaling pathways can exert major effects on lifespan and related life history traits in worms, flies, mice, and other organisms. While most of this research has focused on insulin/insulin-like growth factor-1 signaling, a peptide hormone pathway, recent work has shown that also lipophilic hormones play an important role in modulating lifespan and other life history traits. Here we review how steroid hormones, a particular group of lipophilic hormones, affect life history traits in the nematode worm (Caenorhabditis elegans) and the fruit fly (Drosophila melanogaster), with a particular focus on longevity. Interestingly, a comparison suggests that parallel endocrine principles might be at work in worms and flies in these species and that steroid hormones interact with the gonad to affect lifespan.
Mots-clé
Animals, Caenorhabditis elegans/physiology, Caenorhabditis elegans Proteins/metabolism, Cholestenes/metabolism, Drosophila/physiology, Ecdysterone/metabolism, Gonadal Steroid Hormones/metabolism, Gonads/metabolism, Longevity/physiology, Receptors, Cytoplasmic and Nuclear/metabolism, Receptors, Steroid/metabolism
Pubmed
Web of science
Création de la notice
28/01/2013 12:47
Dernière modification de la notice
03/03/2018 22:36
Données d'usage