Comparison of cannabinoid concentrations in oral fluid and whole blood between occasional and regular cannabis smokers prior to and after smoking a cannabis joint.

Détails

Ressource 1Télécharger: serval:BIB_F01DAEEAD312.P001 (374.81 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
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ID Serval
serval:BIB_F01DAEEAD312
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of cannabinoid concentrations in oral fluid and whole blood between occasional and regular cannabis smokers prior to and after smoking a cannabis joint.
Périodique
Analytical and Bioanalytical Chemistry
Auteur(s)
Fabritius M., Chtioui H., Battistella G., Annoni J.M., Dao K., Favrat B., Fornari E., Lauer E., Maeder P., Giroud C.
ISSN
1618-2642
ISSN-L
1618-2650 (Electronic)
Statut éditorial
Publié
Date de publication
2013
Volume
405
Numéro
30
Pages
9791-9803
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish. pdf type: research paper
Résumé
A cross-over controlled administration study of smoked cannabis was carried out on occasional and heavy smokers. The participants smoked a joint (11 % Δ9-tetrahydrocannabinol (THC)) or a matching placebo on two different occasions. Whole blood (WB) and oral fluid (OF) samples were collected before and up to 3.5 h after smoking the joints. Pharmacokinetic analyses were obtained from these data. Questionnaires assessing the subjective effects were administered to the subjects during each session before and after the smoking time period. THC, 11-hydroxy-THC (11-OH-THC) and 11-nor-9-carboxy-THC (THCCOOH) were analyzed in the blood by gas chromatography or liquid chromatography (LC)-tandem mass spectrometry (MS/MS). The determination of THC, THCCOOH, cannabinol (CBN), and Δ9-tetrahydrocannabinolic acid A (THC-A) was carried out on OF only using LC-MS/MS. In line with the widely accepted assumption that cannabis smoking results in a strong contamination of the oral cavity, we found that THC, and also THC-A, shows a sharp, high concentration peak just after smoking, with a rapid decrease in these levels within 3 h. No obvious differences were found between both groups concerning THC median maximum concentrations measured either in blood or in OF; these levels were equal to 1,338 and 1,041 μg/L in OF and to 82 and 94 μg/L in WB for occasional and heavy smokers, respectively. The initial WB THCCOOH concentration was much higher in regular smokers than in occasional users. Compared with the occasional smokers, the sensation of confusion felt by the regular smokers was much less while the feeling of intoxication remained almost unchanged.
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/12/2013 17:18
Dernière modification de la notice
01/10/2019 6:20
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