Transient and persistent dendritic spines in the neocortex in vivo

Détails

ID Serval
serval:BIB_F006680B53A5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Transient and persistent dendritic spines in the neocortex in vivo
Périodique
Neuron
Auteur(s)
Holtmaat  A. J., Trachtenberg  J. T., Wilbrecht  L., Shepherd  G. M., Zhang  X., Knott  G. W., Svoboda  K.
ISSN
0896-6273 (Print)
Statut éditorial
Publié
Date de publication
01/2005
Volume
45
Numéro
2
Pages
279-91
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jan 20
Résumé
Dendritic spines were imaged over days to months in the apical tufts of neocortical pyramidal neurons (layers 5 and 2/3) in vivo. A fraction of thin spines appeared and disappeared over a few days, while most thick spines persisted for months. In the somatosensory cortex, from postnatal day (PND) 16 to PND 25 spine retractions exceeded additions, resulting in a net loss of spines. The fraction of persistent spines (lifetime > or = 8 days) grew gradually during development and into adulthood (PND 16-25, 35%; PND 35-80, 54%; PND 80-120, 66%; PND 175-225, 73%), providing evidence that synaptic circuits continue to stabilize even in the adult brain, long after the closure of known critical periods. In 6-month-old mice, spines turn over more slowly in visual compared to somatosensory cortex, possibly reflecting differences in the capacity for experience-dependent plasticity in these brain regions.
Mots-clé
Aging/*physiology Animals Animals, Newborn Cell Differentiation/*physiology Dendritic Spines/physiology/*ultrastructure Green Fluorescent Proteins Male Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Fluorescence Neocortex/*growth & development/*ultrastructure Neural Pathways/growth & development/ultrastructure Neuronal Plasticity/physiology Pyramidal Cells/physiology/*ultrastructure Somatosensory Cortex/growth & development/ultrastructure Synapses/physiology/ultrastructure Visual Cortex/growth & development/ultrastructure
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:26
Dernière modification de la notice
09/05/2019 3:14
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