ADC mapping of chronic cerebral hypoperfusion induced by carotid artery stenosis.

Détails

ID Serval
serval:BIB_EFF504CCF9D1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
ADC mapping of chronic cerebral hypoperfusion induced by carotid artery stenosis.
Périodique
Journal of Neuroradiology. Journal de Neuroradiologie
Auteur(s)
Rentsch-Granges V., Assal F., Pereira V.M., Alimenti A., Mosimann P., de Ribaupierre A., Lazeyras F., Becker C.D., Sztajzel R., Rüfenacht D., Lövblad K.O.
ISSN
0150-9861 (Print)
ISSN-L
0150-9861
Statut éditorial
Publié
Date de publication
2011
Volume
38
Numéro
4
Pages
232-237
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
BACKGROUND: Carotid artery stenosis is associated with the occurrence of acute and chronic ischemic lesions that increase with age in the elderly population. Diffusion Imaging and ADC mapping may be an appropriate method to investigate patients with chronic hypoperfusion consecutive to carotid stenosis. This non-invasive technique allows to investigate brain integrity and structure, in particular hypoperfusion induced by carotid stenosis diseases. The aim of this study was to evaluate the impact of a carotid stenosis on the parenchyma using ADC mapping.
METHODS: Fifty-nine patients with symptomatic (33) and asymptomatic (26) carotid stenosis were recruited from our multidisciplinary consultation. Both groups demonstrated a similar degree of stenosis. All patients underwent MRI of the brain including diffusion-weighted MR imaging with ADC mapping. Regions of interest were defined in the anterior and posterior paraventricular regions both ipsilateral and contralateral to the stenosis (anterior circulation). The same analysis was performed for the thalamic and occipital regions (posterior circulation).
RESULTS: ADC values of the affected vascular territory were significantly higher on the side of the stenosis in the periventricular anterior (P<0.001) and posterior (P<0.01) area. There was no difference between ipsilateral and contralateral ADC values in the thalamic and occipital regions.
CONCLUSIONS: We have shown that carotid stenosis is associated with significantly higher ADC values in the anterior circulation, probably reflecting an impact of chronic hypoperfusion on the brain parenchyma in symptomatic and asymptomatic patients. This is consistent with previous data in the literature.
Mots-clé
Aged, Aged, 80 and over, Brain/blood supply, Brain/pathology, Brain Ischemia/etiology, Brain Ischemia/pathology, Carotid Stenosis/complications, Carotid Stenosis/pathology, Cerebrovascular Circulation, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging
Pubmed
Web of science
Création de la notice
05/06/2013 15:40
Dernière modification de la notice
03/03/2018 22:35
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