A new early and automated MRI-based predictor of motor improvement after stroke.

Détails

ID Serval
serval:BIB_EFC53DDD8FFB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A new early and automated MRI-based predictor of motor improvement after stroke.
Périodique
Neurology
Auteur(s)
Granziera C., Daducci A., Meskaldji D.E., Roche A., Maeder P., Michel P., Hadjikhani N., Sorensen A.G., Frackowiak R.S., Thiran J.P., Meuli R., Krueger G.
ISSN
1526-632X (Electronic)
ISSN-L
0028-3878
Statut éditorial
Publié
Date de publication
2012
Volume
79
Numéro
1
Pages
39-46
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
OBJECTIVES: In this study, we investigated the structural plasticity of the contralesional motor network in ischemic stroke patients using diffusion magnetic resonance imaging (MRI) and explored a model that combines a MRI-based metric of contralesional network integrity and clinical data to predict functional outcome at 6 months after stroke.
METHODS: MRI and clinical examinations were performed in 12 patients in the acute phase, at 1 and 6 months after stroke. Twelve age- and gender-matched controls underwent 2 MRIs 1 month apart. Structural remodeling after stroke was assessed using diffusion MRI with an automated measurement of generalized fractional anisotropy (GFA), which was calculated along connections between contralesional cortical motor areas. The predictive model of poststroke functional outcome was computed using a linear regression of acute GFA measures and the clinical assessment.
RESULTS: GFA changes in the contralesional motor tracts were found in all patients and differed significantly from controls (0.001 ≤ p < 0.05). GFA changes in intrahemispheric and interhemispheric motor tracts correlated with age (p ≤ 0.01); those in intrahemispheric motor tracts correlated strongly with clinical scores and stroke sizes (p ≤ 0.001). GFA measured in the acute phase together with a routine motor score and age were a strong predictor of motor outcome at 6 months (r(2) = 0.96, p = 0.0002).
CONCLUSION: These findings represent a proof of principle that contralesional diffusion MRI measures may provide reliable information for personalized rehabilitation planning after ischemic motor stroke. Neurology® 2012;79:39-46.
Pubmed
Web of science
Création de la notice
04/07/2012 15:53
Dernière modification de la notice
20/08/2019 16:17
Données d'usage