Circadian clock genes and the regulation of sleep

Détails

ID Serval
serval:BIB_EFB16D989AB4
Type
Partie de livre
Sous-type
Chapitre: chapitre ou section
Collection
Publications
Titre
Circadian clock genes and the regulation of sleep
Titre du livre
Sleep loss and obesity: intersecting epidemics
Auteur(s)
Curie T., Franken P.
Editeur
Springer
Lieu d'édition
New York
ISBN
978-1-4614-3491-7
Statut éditorial
Publié
Date de publication
2012
Editeur scientifique
Shiromani P.J., Horvath T., Redline S., Van Cauter E.
Numéro de chapitre
1
Pages
1-12
Langue
anglais
Résumé
Sleep and waking are controlled by opposing interactions between circadian and homeostatic processes. A circadian process generated by the suprachiasmatic nucleus determines when sleep should occur, while a homeostatic process keeps track of time spent awake and asleep and signals sleep need or sleep propensity. Recent evidence indicates that these two processes employ many of the same set of genes. Herein, we review the basic concepts of the circadian and homeostatic regulation of sleep, and then outline the molecular components of circadian clock. We then discuss the evidence demonstrating a role of clock genes in sleep homeostasis in flies, mice, and humans. We conclude by suggesting that clock genes might be crucial for integrating homeostatic need, not only that of sleep but also of food intake and energy metabolism.
Création de la notice
17/01/2013 10:26
Dernière modification de la notice
03/03/2018 22:35
Données d'usage