Therapie genique de la greffe cardiaque. [Gene therapy of heart transplantation]

Détails

ID Serval
serval:BIB_EFAB21672612
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Therapie genique de la greffe cardiaque. [Gene therapy of heart transplantation]
Périodique
Revue Médicale de la Suisse Romande
Auteur(s)
Vassalli  G.
ISSN
0035-3655 (Print)
Statut éditorial
Publié
Date de publication
03/2002
Volume
122
Numéro
3
Pages
145-8
Notes
English Abstract
Journal Article
Review --- Old month value: Mar
Résumé
Somatic gene therapy involves the delivery and expression of a protective gene into a somatic organ. Cardiovascular gene therapy currently includes more than twenty clinical trials carried out worldwide. These trials evaluate gene delivery of vascular growth factors to the ischemic heart and legs in patients with coronary and peripheral artery disease, respectively. In contrast, no clinical trials have been carried out in gene therapy of heart transplantation. However, there is increasing experimental evidence for a therapeutic potential of this approach. Using a rat model of heart transplantation, we have shown that gene delivery of an inhibitor of interleukine-1, a pro-inflammatory molecule involved in allograft rejection, results in prolonged allograft survival. Another experimental study (5) has shown that gene transfer of a chimeric molecule comprising the cytotoxic T lymphocytic antigen-4 fused to an immunoglobulin (CTLA-4 Ig), which acts as a suppressor of T lymphocyte co-stimulation, induces an immune tolerance that is selective for the allograft. The recent development of gene transfer vectors that are capable of expressing a transgene for extended periods of time and in a regulatable manner represents an important step towards clinical applications in gene therapy of heart transplantation.
Mots-clé
Adenoviridae Animals Antigens, CD Antigens, Differentiation/immunology Gene Therapy/*methods Genetic Vectors/therapeutic use Graft Rejection/*therapy Heart Transplantation/*immunology Humans Immune Tolerance *Immunoconjugates Interleukin-1/antagonists & inhibitors Models, Animal Rats Transplantation, Homologous
Pubmed
Création de la notice
28/01/2008 11:32
Dernière modification de la notice
03/03/2018 22:35
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