Long-term monitoring of post-stroke plasticity after transient cerebral ischemia in mice using in vivo and ex vivo diffusion tensor MRI.

Détails

Ressource 1Télécharger: BIB_EFAA8CFC006E.P001.pdf (699.74 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_EFAA8CFC006E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Long-term monitoring of post-stroke plasticity after transient cerebral ischemia in mice using in vivo and ex vivo diffusion tensor MRI.
Périodique
Open Neuroimaging Journal
Auteur(s)
Granziera C., D'Arceuil H., Zai L., Magistretti P.J., Sorensen A.G., de Crespigny A.J.
ISSN
1874-4400 (Electronic)
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
1
Pages
10-17
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
WE USED A MURINE MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA TO STUDY: 1) in vivo DTI long-term temporal evolution of the apparent diffusion coefficient (ADC) and diffusion fractional anisotropy (FA) at days 4, 10, 15 and 21 after stroke 2) ex vivo distribution of a plasticity-related protein (GAP-43) and its relationship with the ex vivo DTI characteristics of the striato-thalamic pathway (21 days). All animals recovered motor function. In vivo ADC within the infarct was significantly increased after stroke. In the stroke group, GAP-43 expression and FA values were significantly higher in the ipsilateral (IL) striatum and contralateral (CL) hippocampus compared to the shams. DTI tractography showed fiber trajectories connecting the CL striatum to the stroke region, where increased GAP43 and FA were observed and fiber tracts from the CL striatum terminating in the IL hippocampus.Our data demonstrate that DTI changes parallel histological remodeling and recovery of function.
Pubmed
Création de la notice
10/03/2012 20:46
Dernière modification de la notice
03/03/2018 22:35
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