Bone mineral density (BMD) and vertebral trabecular bone score (TBS) for the identification of elderly women at high risk for fracture: the SEMOF cohort study.

Détails

ID Serval
serval:BIB_EFA45C5F44EE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Bone mineral density (BMD) and vertebral trabecular bone score (TBS) for the identification of elderly women at high risk for fracture: the SEMOF cohort study.
Périodique
European spine journal
Auteur(s)
Popp A.W., Meer S., Krieg M.A., Perrelet R., Hans D., Lippuner K.
ISSN
1432-0932 (Electronic)
ISSN-L
0940-6719
Statut éditorial
Publié
Date de publication
11/2016
Peer-reviewed
Oui
Volume
25
Numéro
11
Pages
3432-3438
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To determine the predictive value of the vertebral trabecular bone score (TBS) alone or in addition to bone mineral density (BMD) with regard to fracture risk.
Retrospective analysis of the relative contribution of BMD [measured at the femoral neck (FN), total hip (TH), and lumbar spine (LS)] and TBS with regard to the risk of incident clinical fractures in a representative cohort of elderly post-menopausal women previously participating in the Swiss Evaluation of the Methods of Measurement of Osteoporotic Fracture Risk study.
Complete datasets were available for 556 of 701 women (79 %). Mean age 76.1 years, LS BMD 0.863 g/cm2, and TBS 1.195. LS BMD and LS TBS were moderately correlated (r 2 = 0.25). After a mean of 2.7 ± 0.8 years of follow-up, the incidence of fragility fractures was 9.4 %. Age- and BMI-adjusted hazard ratios per standard deviation decrease (95 % confidence intervals) were 1.58 (1.16-2.16), 1.77 (1.31-2.39), and 1.59 (1.21-2.09) for LS, FN, and TH BMD, respectively, and 2.01 (1.54-2.63) for TBS. Whereas 58 and 60 % of fragility fractures occurred in women with BMD T score ≤-2.5 and a TBS <1.150, respectively, combining these two thresholds identified 77 % of all women with an osteoporotic fracture.
Lumbar spine TBS alone or in combination with BMD predicted incident clinical fracture risk in a representative population-based sample of elderly post-menopausal women.

Mots-clé
Aged, Bone Density/physiology, Cancellous Bone/pathology, Female, Humans, Lumbar Vertebrae/pathology, Osteoporosis/pathology, Osteoporotic Fractures/epidemiology, Osteoporotic Fractures/prevention & control, Retrospective Studies, Risk Factors, Bone mineral density, Fracture risk, Osteoporosis, Trabecular bone score
Pubmed
Web of science
Création de la notice
28/10/2015 15:24
Dernière modification de la notice
03/03/2018 22:35
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