Hepatitis B virus in transfusion medicine: still a problem?

Détails

ID Serval
serval:BIB_EF8625147718
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Hepatitis B virus in transfusion medicine: still a problem?
Périodique
Biologicals : Journal of the International Association of Biological Standardization
Auteur(s)
Allain J.P., Candotti D.
Collaborateur(s)
ISBT HBV Safety Collaborative Group
Contributeur(s)
Abolghasemi H., Arslan O., Ayob Y., Belkhiri D., Bianco L., Bird A., Bon EH., Boukef K., Brojer E., Crookes R., Dodd R., Echevarria JM., El Chaar M., ElEkiaby M., ElSiddigh A., Erikstrup C., Foglieni B., Garmiri P., Ghiazza P., Gonzales-Fraile I., Grabarczyk P., Harritshøj LH., Hatzakis A., Hullum J., Iudicone P., Lam S., Laperche S., Lelie N., Levi J., Levicnik-Stezinar S., Li C., Lin CK., Lin SJ., Loua A., Manzini P., Meldal B., Mihaljevic I., Niederhauser C., O'Brien S., Osselaer JC., Owusu-Ofori S., Pischl L., Prati D., Roig R., Sakul T., Sauleda S., Schmidt S., Stolz M., Stramer S., Vessberg S., Teo D., Tedder R., Vermeulen M., Wendel S., Zadeh H.
ISSN
1095-8320 (Electronic)
ISSN-L
1045-1056
Statut éditorial
Publié
Date de publication
2012
Volume
40
Numéro
3
Pages
180-186
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Hepatitis B virus (HBV) has probably evolved with humans for nearly 35,000 years. HBV diversified into 9 genotypes (A-I) presenting specific features directing epidemiology, clinical expression and testing. Genotypes E and C are more infectious and carry higher risk of chronicity and cancer. HBsAg blood screening implemented 40 years ago enormously decreased the risk of transfusion transmission but the remaining risk requires extremely sensitive nucleic acid testing (NAT) to be removed. Limitations of the host immune system, the impact of immunodeficiency and the mechanisms utilised for viral persistence were recently identified. HBV replication produces excess HBsAg and infectious and defective viral particles but screening assays for HBsAg or viral particles alone do not allow fully efficient detection, making necessary screening for both. The host immune system fails to completely control the virus that escapes and persists unrecognized at very low levels or as immuno-selected variants. Variants may not be identified by assays, explaining false negative results. Specific mutations may affect post-transcriptional mechanisms including HBV RNA splicing. Asymptomatic HBV infected blood donors are at risk of long-term complications through mechanisms to be understood for appropriate counselling. Infectivity of occult HBV infection (OBI) by transfusion appears low, anti-HBc (anti-core antigen) only being more infectious than anti-HBs (anti-S protein) positive units.
Mots-clé
Blood Donors, Blood Transfusion, DNA, Viral/blood, DNA, Viral/genetics, Genetic Testing/methods, Hepatitis B/blood, Hepatitis B/diagnosis, Hepatitis B virus/genetics, Humans, Sensitivity and Specificity
Pubmed
Web of science
Création de la notice
09/11/2014 16:53
Dernière modification de la notice
03/03/2018 22:34
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