Detection in urine of 4-methyl-2-hexaneamine, a doping agent.

Détails

ID Serval
serval:BIB_EF71E19CF71C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Detection in urine of 4-methyl-2-hexaneamine, a doping agent.
Périodique
Journal of Chromatography. B
Auteur(s)
Perrenoud L., Saugy M., Saudan C.
ISSN
1570-0232
Statut éditorial
Publié
Date de publication
2009
Volume
877
Numéro
29
Pages
3767-3770
Langue
anglais
Résumé
Stimulants are banned in-competition for all categories of sports by the World Anti-Doping Agency. A simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay employing electrospray ionisation in positive mode was developed in that work for the quantification in urine specimens of 4-methyl-2-hexaneamine, a primary amine exhibiting sympathomimetic properties. Following a simple pretreatment procedure, the analyte was separated using a gradient mobile phase on reverse phase C8 column. Selected reaction monitoring m/z 116.2-->57.3 was specific for detection of 4-methyl-2-hexaneamine and the assay exhibited a linear dynamic range of 50-700 ng/mL. The validated method has been successfully applied to analyze the target compound in food supplements as well as in urine specimens. The administered drug (40 mg) was detected at the level of 350 ng/mL in the urine up to 4 days.
Mots-clé
Doping, Stimulant, Mass spectrometry, Liquid chromatography, Gas chromatography
Pubmed
Web of science
Création de la notice
10/11/2009 14:49
Dernière modification de la notice
03/03/2018 22:34
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