Les biomarqueurs du liquide céphalo-rachidien dans la maladie d'Alzheimer en pratique clinique courante [Cerebrospinal fluid biomarkers of Alzheimer's disease in current clinical practice].

Détails

ID Serval
serval:BIB_EF61DD096D14
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Les biomarqueurs du liquide céphalo-rachidien dans la maladie d'Alzheimer en pratique clinique courante [Cerebrospinal fluid biomarkers of Alzheimer's disease in current clinical practice].
Périodique
Revue Medicale Suisse
Auteur(s)
Magnin E., Popp J.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
04/2016
Peer-reviewed
Oui
Volume
12
Numéro
515
Pages
791-794
Langue
français
Notes
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish
Résumé
The cerebrospinal fluid levels of amyloid beta 1-42 (Aβ1-42), total tau and tau phosphorylated at threonine 181 (ptau181) are well established biomarkers of cerebral amyloid pathology and tau related neurodegeneration, two hallmarks of Alzheimer's disease. These biomarkers can help to improve diagnostic accuracy and consequent decisions on counseling, support, and therapy of patients with mild cognitive impairment and dementia. The use of biomarkers is part of the proposed new criteria of AD diagnosis. It may be particularly helpful in cases of atypical clinical presentation and uncertain diagnosis, and if an important benefit for the patient is expected. The ongoing development of new biomarkers based on less or non-invasive procedures will allow for a larger use of biomarkers to improve the diagnosis of cognitive impairment.
Mots-clé
Alzheimer Disease/cerebrospinal fluid, Alzheimer Disease/diagnosis, Amyloid beta-Peptides/cerebrospinal fluid, Biomarkers/cerebrospinal fluid, Cognitive Therapy/methods, Diagnosis, Differential, Early Diagnosis, Humans, Predictive Value of Tests, Sensitivity and Specificity, tau Proteins/cerebrospinal fluid
Pubmed
Création de la notice
20/04/2016 17:44
Dernière modification de la notice
03/03/2018 22:34
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