Article: article from journal or magazin.
Modulation of markers associated with tumor aggressiveness in human breast cancer cell lines by N-(4-hydroxyphenyl) retinamide
Cell Growth and Differentiation
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jul
The retinoid N-(hydroxyphenyl) retinamide (4-HPR) appears to be a promising tool for chemoprevention of breast carcinoma, and clinical trials to evaluate its effect are in progress. However, its action on tumor cells has remained largely undefined. We report here that 4-HPR induced apoptosis and/or differentiation in breast cancer cell lines, independent of hormone receptor status and retinoic acid receptor expression, although it was slightly more efficient in inhibiting proliferation of estrogen receptor-positive cells. 4-HPR up-modulated expression of several differentiation markers (class 1 HLA, laminin, and beta 1 integrin chain) and down-regulated expression of molecules associated with tumor progression, including the p185/HER2 oncoprotein, the epidermal growth factor receptor, and the M(r) 67,000 laminin receptor. These data suggest that 4-HPR could exert a beneficial effect by inhibiting cell proliferation and modulating breast tumor aggressiveness.
Anticarcinogenic Agents/*pharmacology Apoptosis/drug effects Blotting, Northern Breast Neoplasms/*pathology Cell Differentiation/drug effects Cell Division/drug effects Fenretinide/*pharmacology Gene Expression/physiology Humans Receptors, Estrogen/physiology Receptors, Progesterone/physiology Tumor Cells, Cultured/drug effects *Tumor Markers, Biological
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