Studies of the association of the A, B and Lewis Blood group antigens with carcinoembryonic antigen (CEA).

Détails

ID Serval
serval:BIB_EF2D0FCB2E10
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Studies of the association of the A, B and Lewis Blood group antigens with carcinoembryonic antigen (CEA).
Périodique
Immunology
Auteur(s)
Holburn A.M., Mach J.P., MacDonald D., Newlands M.
ISSN
0019-2805 (Print)
ISSN-L
0019-2805
Statut éditorial
Publié
Date de publication
1974
Volume
26
Numéro
4
Pages
831-843
Langue
anglais
Résumé
Carcinoembryonic antigen (CEA) was purified from primary tumour or from hepatic metastases obtained from ten cases of carcinoma of the colon. In nine cases the blood group antigens A, B, Lea or Leb were detected in CEA preparations by the binding of 125I-labelled CEA by blood group antibodies. The extent of binding appeared to preclude simple contamination of CEA preparations by blood group glycoprotein. In all cases the blood group antigens detected were consistent with the patients' known blood groups. Blood group I and i activities were not detected.
It is concluded that the determinants of A, B and Lewis antigens and of CEA share the same glycoprotein carrier molecules.
Mots-clé
ABO Blood-Group System, Animals, Antigen-Antibody Reactions, Carcinoembryonic Antigen, Colonic Neoplasms/immunology, Cross Reactions, Glycoproteins, Goats/immunology, Humans, Immune Sera, Iodine Radioisotopes, Isoantigens, Lewis Blood-Group System, Radioimmunoassay
Pubmed
Web of science
Création de la notice
24/04/2013 11:23
Dernière modification de la notice
03/03/2018 22:34
Données d'usage