Studies of the association of the A, B and Lewis Blood group antigens with carcinoembryonic antigen (CEA).
Details
Serval ID
serval:BIB_EF2D0FCB2E10
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Studies of the association of the A, B and Lewis Blood group antigens with carcinoembryonic antigen (CEA).
Journal
Immunology
ISSN
0019-2805 (Print)
ISSN-L
0019-2805
Publication state
Published
Issued date
1974
Volume
26
Number
4
Pages
831-843
Language
english
Abstract
Carcinoembryonic antigen (CEA) was purified from primary tumour or from hepatic metastases obtained from ten cases of carcinoma of the colon. In nine cases the blood group antigens A, B, Lea or Leb were detected in CEA preparations by the binding of 125I-labelled CEA by blood group antibodies. The extent of binding appeared to preclude simple contamination of CEA preparations by blood group glycoprotein. In all cases the blood group antigens detected were consistent with the patients' known blood groups. Blood group I and i activities were not detected.
It is concluded that the determinants of A, B and Lewis antigens and of CEA share the same glycoprotein carrier molecules.
It is concluded that the determinants of A, B and Lewis antigens and of CEA share the same glycoprotein carrier molecules.
Keywords
ABO Blood-Group System, Animals, Antigen-Antibody Reactions, Carcinoembryonic Antigen, Colonic Neoplasms/immunology, Cross Reactions, Glycoproteins, Goats/immunology, Humans, Immune Sera, Iodine Radioisotopes, Isoantigens, Lewis Blood-Group System, Radioimmunoassay
Pubmed
Web of science
Create date
24/04/2013 11:23
Last modification date
20/08/2019 17:16
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