Role of neutrophils in the early shaping of the Leishmania major specific immune response in experimental murine cutaneous Leishmaniasis

Détails

ID Serval
serval:BIB_EF1A2538E419
Type
Partie de livre
Collection
Publications
Titre
Role of neutrophils in the early shaping of the Leishmania major specific immune response in experimental murine cutaneous Leishmaniasis
Titre du livre
Neutrophils in infectious diseases
Auteur(s)
Charmoy M, Milon G., Tacchini-Cottier F.
Editeur
Bentham e Books
ISBN
e 978-1-60805-023-9
Statut éditorial
Publié
Date de publication
2011
Editeur scientifique
Tacchini-Cottier F., van Zandbergen G.
Pages
49-58
Langue
anglais
Résumé
The development of a protective immune response to microorganisms involves complex interactions between the host and the pathogen. The murine model of infection with Leishmania major (L. major) allows the study of the factors leading to the development of a protective immune response. Following infection with the protozoan parasite L. major, most strains of mice heal their lesions, while a few fail to control infection, both processes linked to the development of specific T helper subsets. The early events occurring during the first days following parasite inoculation are thought to be critical in the development of the Leishmania-specific immune response. Neutrophils are the first cells arriving massively to the site of infection, and recent evidence points to their role as organizers of the immune response, yet their specific role in this process remains elusive. Through interactions with cells present at the parasite inoculation site, and possibly within the draining lymph nodes, neutrophils could have an impact not only on the recruitment of inflammatory cells but also on the activation of local as well as newly migrated cells that will be crucial in shaping the Leishmania-specific immune response.
Open Access
Oui
Création de la notice
09/02/2012 12:19
Dernière modification de la notice
09/05/2019 3:11
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