Pulmonary Hypertension and Indicators of Right Ventricular Function.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_EEF46332F470
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Pulmonary Hypertension and Indicators of Right Ventricular Function.
Périodique
Frontiers In Medicine
Auteur(s)
von Siebenthal C., Aubert J.D., Mitsakis P., Yerly P., Prior J.O., Nicod L.P.
ISSN
2296-858X (Electronic)
ISSN-L
2296-858X
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
3
Pages
23
Langue
anglais
Résumé
Pulmonary hypertension (PH) is a rare disease, whose underlying mechanisms are not fully understood. It is characterized by pulmonary arterial vasoconstriction and vessels wall thickening, mainly intimal and medial layers. Several molecular pathways have been studied, but their respective roles remain unknown. Cardiac repercussions of PH are hypertrophy, dilation, and progressive right ventricular dysfunction. Multiple echocardiographic parameters are being used, in order to assess anatomy and cardiac function, but there are no guidelines edited about their usefulness. Thus, it is now recommended to associate the best-known parameters, such as atrial and ventricular diameters or tricuspid annular plane systolic excursion. Cardiac catheterization remains necessary to establish the diagnosis of PH and to assess pulmonary hemodynamic state. Concerning energetic metabolism, free fatty acids, normally used to provide energy for myocardial contraction, are replaced by glucose uptake. These abnormalities are illustrated by increased (18)F-fluorodeoxyglucose ((18)F-FDG) uptake on positron emission tomography/computed tomography, which seems to be correlated with echocardiographic and hemodynamic parameters.
Pubmed
Open Access
Oui
Création de la notice
07/07/2016 13:55
Dernière modification de la notice
09/05/2019 3:11
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