Familiality of symptom dimensions in depression

Détails

ID Serval
serval:BIB_EEE4B0EAD020
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Familiality of symptom dimensions in depression
Périodique
Archives of General Psychiatry
Auteur(s)
Korszun Ania, Moskvina Valentina, Brewster Shyama, Craddock Nick, Ferrero François, Gill Michael, Jones Ian Richard, Jones Lisa Anne, Maier Wolfgang, Mors Ole, Owen Michael J., Preisig Martin, Reich Theodore, Rietschel Marcella, Farmer Anne, McGuffin Peter
ISSN
0003-990X
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
61
Numéro
5
Pages
468-474
Langue
anglais
Notes
SAPHIRID:62847
Résumé
BACKGROUND: Depression is a clinically heterogeneous disorder thought to result from multiple genes interacting with environmental and developmental components. A dimensional rather than a categorical approach to depressive phenotype definition may be more useful for identification of susceptibility genes. OBJECTIVES: To perform an exploratory factor analysis on a range of depressive and anxiety symptoms in a large, well-defined sample of depressed siblings, as well as a confirmatory factor analysis in a separate large group of unrelated depressed subjects, and to analyze correlations of identified symptom dimensions between depressed siblings. DESIGN: Subjects (N = 1034), including 475 sibling pairs, with a history of at least 2 depressive episodes were recruited from the Depression Network Study, a large-scale multicenter collection of families affected by recurrent unipolar depression. Subjects were interviewed using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and diagnosed according to the DSM-IV and the International Classification of Diseases, 10th Revision, using a computerized scoring program (CATEGO5). Factor analysis was carried out on 26 depression symptom items, including 4 anxiety screening items. Confirmatory factor analysis was performed on an independent sample of 485 depressed individuals. RESULTS: Four interpretable factors were identified: (1) mood symptoms and psychomotor retardation; (2) anxiety; (3) psychomotor agitation, guilt, and suicidality; and (4) appetite gain and hypersomnia. For each symptom group, a quantitative scale was constructed, and correlations between siblings were calculated. There was a moderate degree of sibling homotypia for some depressive symptoms, and factors 1, 2, and 3 showed significant positive familial correlation (0.145 [P =.001], 0.335 [P<.001], and 0.362 [P<.001], respectively). CONCLUSIONS: This is the first study of large, well-defined samples of depressed subjects in whom symptom dimensions have been derived and then confirmed using independent material. The significant correlations between siblings for 3 of the dimensions suggest substantial familial, perhaps genetic, etiologies.
Pubmed
Web of science
Création de la notice
13/03/2008 9:39
Dernière modification de la notice
03/03/2018 22:33
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