Le cancer colorectal hereditaire non polyposique. [Hereditary nonpolyposis colorectal cancers]

Détails

ID Serval
serval:BIB_EED9CDF6E416
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Le cancer colorectal hereditaire non polyposique. [Hereditary nonpolyposis colorectal cancers]
Périodique
Schweizerische Rundschau fur Medizin Praxis
Auteur(s)
Caplin  S., Constanda  M. T., Givel  J. C.
ISSN
1013-2058 (Print)
Statut éditorial
Publié
Date de publication
08/1996
Volume
85
Numéro
35
Pages
1041-5
Notes
English Abstract
Journal Article
Review --- Old month value: Aug 27
Résumé
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal, dominantly inherited disease leading to a marked increase in cancer susceptibility, notably colorectal cancer, affecting up to one in 400 individuals in the Western world. Four genes responsible for the majority of cases have been identified. Colorectal cancer in affected people tends to be right sided, occur at an earlier age, and there is a propensity for synchronous or metachronous lesions. Extra-colonic tumours may occur with an elevated frequency, most importantly cancer of the endometrium, but also stomach, hepatobiliary system, small bowel, proximal ureter and renal pelvis, and ovary. On account of these features, management guidelines for members of HNPCC kindreds require modification from those generally advised for patients with sporadic tumours. The cardinal feature for the identification of affected families is the family history. All clinicians have a duty to identify such patients under their care as appropriate screening and surgery should lead to an improved prognosis for such patients and their families.
Mots-clé
Adult Aged Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics Female *Genes, Dominant Humans Male Middle Aged Neoplasms, Multiple Primary/genetics Neoplastic Syndromes, Hereditary/genetics Pedigree Prognosis
Pubmed
Création de la notice
28/01/2008 9:56
Dernière modification de la notice
03/03/2018 22:33
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