Distribution of vasopressin and oxytocin receptors in the rat spinal cord: sex-related differences and effect of castration in pudendal motor nuclei

Détails

ID Serval
serval:BIB_EECCFF86C98F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Distribution of vasopressin and oxytocin receptors in the rat spinal cord: sex-related differences and effect of castration in pudendal motor nuclei
Périodique
Neuroscience
Auteur(s)
Tribollet  E., Barberis  C., Arsenijevic  Y.
ISSN
0306-4522 (Print)
Statut éditorial
Publié
Date de publication
05/1997
Volume
78
Numéro
2
Pages
499-509
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
The distribution of vasopressin and oxytocin receptors was established by in vitro autoradiography in the spinal cord of adult rats of either sex, as well as in male castrates. In both males and females, high concentrations of vasopressin binding sites were found in a few groups of somatic motoneurons: the large lateral group at the cervicothoracic junction in segments C8 and Th1; the small medial group in segments L3-L5; and the pudendal and retrodorsolateral nuclei in segments L5-L6. The extension and intensity of labelling in pudendal nuclei were markedly lower in females than in males, in particular in the dorsomedial nucleus, where binding was either not or hardly detectable. Gonadectomy in males resulted in a significant reduction of binding in pudendal nuclei, but not in other labelled motor nuclei. Moderate amounts of vasopressin binding sites were also found evenly distributed throughout the central gray at all segmental levels. Oxytocin binding sites were detectable in all spinal segments, but in low amounts and restricted to the superficial layers of the dorsal horn. The abundance of vasopressin binding sites in the central gray suggests that vasopressin may be involved in most spinal functions. The permanent expression of vasopressin binding sites in pudendal motor nuclei of is particular interest with regard to the known plasticity of pudendal motoneurons.
Mots-clé
Animals Autoradiography Female Iodine Radioisotopes/diagnostic use Ligands Male *Orchiectomy *Ovariectomy Rats Rats, Sprague-Dawley Receptors, Oxytocin/*metabolism Receptors, Vasopressin/*metabolism Sex Characteristics Spinal Cord/*anatomy & histology/*metabolism Spinal Nerves/metabolism/*physiology Vasopressins/metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 13:31
Dernière modification de la notice
03/03/2018 22:33
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