Activation-dependent epitopes in the terminal complement pathway

Détails

ID Serval
serval:BIB_EEB2BCAE535D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Activation-dependent epitopes in the terminal complement pathway
Périodique
Complement and Inflammation
Auteur(s)
Mollnes  T. E., Lea  T., Tschopp  J.
ISSN
1012-8204 (Print)
Statut éditorial
Publié
Date de publication
1989
Volume
6
Numéro
3
Pages
223-35
Notes
Journal Article
Review
Résumé
Assembly of the terminal complement complex (TCC) during complement activation is associated with considerable antigenic changes in the individual C5, C6, C7, C8 and C9 components. Numerous neoepitopes specific for the TCC are exposed. Similarly, native-restricted epitopes specific for the nonactivated components are concealed in the TCC. The present paper reviews these antigenic changes with special reference to available monoclonal antibodies and their utilization in assays to detect and quantify the TCC. Application of such assays in clinical medicine is discussed. Finally, a recommended terminology for the terminal complement pathway is put forward.
Mots-clé
Antibodies, Monoclonal *Complement Activation Complement C5/immunology Complement C5b Complement C9/immunology Complement Membrane Attack Complex Complement System Proteins/analysis/*immunology Epitopes/*metabolism Humans Immunohistochemistry
Pubmed
Web of science
Création de la notice
24/01/2008 16:19
Dernière modification de la notice
03/03/2018 22:33
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