Emerging therapies for gout.

Détails

ID Serval
serval:BIB_EEA4E92F1C87
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Emerging therapies for gout.
Périodique
Rheumatic Diseases Clinics of North America
Auteur(s)
Edwards N.L., So A.
ISSN
1558-3163 (Electronic)
ISSN-L
0889-857X
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
40
Numéro
2
Pages
375-387
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Over the past decade much has been learned about the mechanisms of crystal-induced inflammation and renal excretion of uric acid, which has led to more specific targeting of gout therapies and a more potent approach to future management of gout. This article outlines agents being developed for more aggressive lowering of urate and more specific anti-inflammatory activity. The emerging urate-lowering therapies include lesinurad, arhalofenate, ulodesine, and levotofisopam. Novel gout-specific anti-inflammatories include the interleukin-1β inhibitors anakinra, canakinumab, and rilonacept, the melanocortins, and caspase inhibitors. The historic shortcomings of current gout treatment may, in part, be overcome by these novel approaches.
Mots-clé
Acetamides/therapeutic use, Adrenocorticotropic Hormone/therapeutic use, Antibodies, Monoclonal/therapeutic use, Antirheumatic Agents/therapeutic use, Benzodiazepines/therapeutic use, Gout/drug therapy, Gout Suppressants/therapeutic use, Humans, Imino Furanoses/therapeutic use, Interleukin 1 Receptor Antagonist Protein/therapeutic use, Interleukin-1beta/antagonists & inhibitors, Melanocortins/therapeutic use, Phenylacetates/therapeutic use, Polyethylene Glycols, Pyrimidinones/therapeutic use, Recombinant Fusion Proteins/therapeutic use, Thiazoles, Thioglycolates/therapeutic use, Triazoles/therapeutic use, Urate Oxidase, Uricosuric Agents/therapeutic use
Pubmed
Web of science
Création de la notice
15/01/2015 13:13
Dernière modification de la notice
03/03/2018 22:33
Données d'usage