Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?

Détails

ID Serval
serval:BIB_EEA03BB28207
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?
Périodique
Oncogene
Auteur(s)
Meroni G., Cairo S., Merla G., Messali S., Brent R., Ballabio A., Reymond A.
ISSN
0950-9232 (Print)
ISSN-L
0950-9232
Statut éditorial
Publié
Date de publication
2000
Volume
19
Numéro
29
Pages
3266-3277
Langue
anglais
Résumé
The Myc proto-oncogene family members have been identified as the cellular homologs of the transforming oncogene of avian retroviruses. They encode central regulators of mammalian cell proliferation and apoptosis, and they associate with the bHLHZip protein Max to bind specific DNA sequences and regulate the expression of genes important for cell cycle progression. The other family members, Mad1, Mxi1, Mad3, Mad4 and Rox (Mnt) antagonize their activities. The Mads and Rox compete with Myc in heterodimerizing with Max and in binding to the same specific target sequences. These Mads:Max and Rox:Max dimers repress transcription through binding to the mSIN3 corepressor protein and by tethering histone deacetylase-containing complexes to the DNA. In a screen for Rox interactors we isolated Mlx, a bHLHZip protein previously identified in a screen for Mad1 interactors. In the present work we extend the known dimerization partners of Mlx by demonstrating its ability to interact with Rox. Moreover, we show that contrary to previous reports Mlx is able to homodimerize and to bind E-box sequences at low concentration levels. The possible role of Mlx in an emerging regulatory pathway and acting parallel to the Max driven network is discussed.
Mots-clé
Amino Acid Sequence, Animals, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Basic-Leucine Zipper Transcription Factors, COS Cells, Cell Line, Transformed, DNA/metabolism, DNA, Complementary, DNA-Binding Proteins/genetics, DNA-Binding Proteins/metabolism, Dimerization, Gene Expression, Genes, Suppressor, Hela Cells, Helix-Loop-Helix Motifs, Humans, Leucine Zippers, Molecular Sequence Data, Nuclear Proteins/metabolism, Protein Isoforms/genetics, Protein Isoforms/metabolism, Rabbits, Repressor Proteins, Signal Transduction, Subcellular Fractions, Transcription Factors/genetics, Transcription Factors/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:51
Dernière modification de la notice
09/05/2019 3:09
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