Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET.

Détails

ID Serval
serval:BIB_EE99FCA9C02B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET.
Périodique
Journal of Neuroscience
Auteur(s)
Grafton S.T., Mazziotta J.C., Presty S., Friston K.J., Frackowiak R.S., Phelps M.E.
ISSN
0270-6474 (Print)
ISSN-L
0270-6474
Statut éditorial
Publié
Date de publication
1992
Volume
12
Numéro
7
Pages
2542-2548
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
The functional anatomy of motor skill acquisition was investigated in six normal human subjects who learned to perform a pursuit rotor task with their dominant right hand during serial positron emission tomography (PET) imaging of relative cerebral blood flow (relCBF). The effect of motor execution, rather than learning, was identified by a comparison of four motor performance scans with two control scans (eye movements only). Motor execution was associated with activation of a distributed network involving cortical, striatonigral, and cerebellar sites. Second, the effect of early motor learning was examined. Performance improved from 17% to 66% mean time on target across the four PET scans obtained during pursuit rotor performance. Across the same scans, significant longitudinal increases of relCBF were located in the left primary motor cortex, the left supplementary motor area, and the left pulvinar thalamus. The results demonstrate that changes of regional cerebral activity associated with early learning of skilled movements occur in sites that are a subset of a more widely distributed network that is active during motor execution.
Mots-clé
Adult, Brain/anatomy & histology, Brain/blood supply, Brain Mapping, Cerebrovascular Circulation, Eye Movements, Female, Functional Laterality, Humans, Learning/physiology, Male, Motor Activity, Movement, Organ Specificity, Regional Blood Flow, Tomography, Emission-Computed/methods
Pubmed
Web of science
Création de la notice
25/09/2011 17:09
Dernière modification de la notice
03/03/2018 22:33
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