Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Schizophrenia, neurodevelopment and corpus callosum
AN - Peer Reviewed Journal: 2003-08850-007 MA - Innocenti [G. M.: Giorgio.Innocenti@neuro.ki.se LG - English Empirical Study. Quantitative Study. Journal Article PT - Peer Reviewed Journal RF - Agartz, I., Andersson, J. L. R., & Skasre, S. (2001). Abnormal brain white matter in schizophrenia: a diffusor tensor imaging study. Neuroreport: An International Journal for the Rapid Communication of Research in Neuroscience 2001; 12: 2251-2254 Institution : Division of Neuroanatomy and Brain Development, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden SUPEA, Unite de Pedopsychiatrie de liaison, Hopital Nestle, Lausanne-CHUV, Switzerland Cognitive Research Unit, Copenhagen University Department of Psychiatry, Hvidovre Hospital, Brondby, Denmark SAPHIRID:48150
(from the journal abstract) The Zeitgeist favors an interpretation of schizophrenia as a condition of abnormal connectivity of cortical neurons, particularly in the prefrontal and temporal cortex. The available evidence points to reduced connectivity, a possible consequence of excessive synaptic pruning in development. A decreased thalamic input to the cerebral cortex appears likely, and developmental studies predict that this decrease should entail a secondary loss of both long- and short-range cortico-cortical connections, including connections between the hemispheres. Indeed, morphological, electrophysiological and neuropsychological studies over the last two decades suggest that the callosal connections are altered in schizophrenics. However, the alterations are subtle and sometimes inconsistent across studies, and need to be investigated further with new methodologies. (PsycINFO Database Record (c) 2004 APA, all rights reserved)
Web of science
Last modification date