Analgesie postoperatoire pour cholecystectomie sous coelioscopie: comparaison de l'administration preoperatoire du celecoxib et du paracetamol [Postoperative analgesia after laparoscopic cholecystectomy: comparison of the preoperative administration of celecoxib with paracetamol?]

Details

Serval ID
serval:BIB_EE1213F3C348
Type
Article: article from journal or magazin.
Collection
Publications
Title
Analgesie postoperatoire pour cholecystectomie sous coelioscopie: comparaison de l'administration preoperatoire du celecoxib et du paracetamol [Postoperative analgesia after laparoscopic cholecystectomy: comparison of the preoperative administration of celecoxib with paracetamol?]
Journal
La Tunisie medicale
Author(s)
Sami Mebazaa M., Frikha N., Ben Hammouda N., Mestiri T., Mestiri H., Khalfallah T., Ben Ammar M.S.
ISSN
0041-4131 (Print)
ISSN-L
0041-4131
Publication state
Published
Issued date
10/2008
Peer-reviewed
Oui
Volume
86
Number
10
Pages
869-873
Language
french
Notes
Publication types: Comparative Study ; English Abstract ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
The goal of this study was to evaluate the preventive analgesic effectiveness of paracetamol and celecoxib in laparoscopic cholecystectomy.
Randomized prospective study was undertaken, 75 patients of class ASA I and II were included, divided into three groups: P (Paracetamol 1000 mg), C (Celecoxib 200 mg) given orally one hour before induction and group T (without preoperative analgesia). The VAS at rest and effort was noted on arrival in the recovery room then with regular intervals (T(30mn) to T(h24). A morphine titration was carried out during the first 12 postoperative hours. Hemodynamic parameters, Ramsay score and the adverse effects were noted.
The three groups were comparable for the demographic data, the duration of anesthesia and peroperative morphine consumption. The evolution of VAS scores shows a significant difference between the groups P and T with the effort of cough at t24h (p = 0.04), and between the groups C and T at postoperative T 4h (p = 0.016). In our study the group C consumed to a significant degree less morphine 5.44 +/- 3.00 Mg against 7.83 +/- 4.00 Mg for the group P (p < 0.03) and 8.04 +/- 3.00 Mg for the group T (p < 0.008).
The administration of 200 Mg of celecoxib in the preoperative period of a laparoscopic cholecystectomy allows a significant decrease in morphine consumption in the postoperative period and a reduction in the scores of the VAS at rest and at the effort of cough compared to the groups which received only one placebo or paracetamol.

Keywords
Acetaminophen/therapeutic use, Adolescent, Adult, Aged, Analgesics, Non-Narcotic/therapeutic use, Anti-Inflammatory Agents, Non-Steroidal/therapeutic use, Celecoxib, Cholecystectomy, Laparoscopic/adverse effects, Female, Humans, Male, Middle Aged, Pain, Postoperative/drug therapy, Pain, Postoperative/etiology, Prospective Studies, Pyrazoles/therapeutic use, Sulfonamides/therapeutic use, Young Adult
Pubmed
Create date
18/07/2016 9:14
Last modification date
20/08/2019 16:15
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