High intralesional interleukin-10 messenger RNA expression in localized cutaneous leishmaniasis is associated with unresponsiveness to treatment.
Details
Serval ID
serval:BIB_EDF83B7D9802
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High intralesional interleukin-10 messenger RNA expression in localized cutaneous leishmaniasis is associated with unresponsiveness to treatment.
Journal
Journal of Infectious Diseases
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Publication state
Published
Issued date
2001
Volume
184
Number
12
Pages
1628-1630
Language
english
Abstract
The intralesional expression of cytokines (interleukin [IL]-4, IL-13, IL-10, and interferon-gamma) was analyzed in 65 patients with localized cutaneous leishmaniasis due to Leishmania guyanensis before specific treatment with pentamidine isethionate. The local expression of IL-10 was significantly higher in patients who responded poorly to treatment than in patients whose lesions were regressing. When an IL-10 level >10 (ratio of the concentration of IL-10 [pg/microL] to that of beta-actin [pg/microL]) was used as an indicator of treatment failure, the sensitivity of this test was 78.6, and the specificity was 72.5. Thus, high intralesional expression of IL-10 might predict a poor response to conventional treatment.
Keywords
Adolescent, Adult, Animals, Antiprotozoal Agents/therapeutic use, Child, Cytokines/metabolism, Female, Humans, Interleukin-10/genetics, Interleukin-10/metabolism, Leishmania guyanensis/drug effects, Leishmaniasis, Cutaneous/drug therapy, Leishmaniasis, Cutaneous/immunology, Male, Middle Aged, Pentamidine/therapeutic use, RNA, Messenger/genetics, RNA, Messenger/metabolism, Treatment Failure
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 12:06
Last modification date
20/08/2019 17:15