Expansion of gamma delta+ T cells in BALB/c mice infected with Leishmania major is dependent upon Th2-type CD4+ T cells.

Détails

ID Serval
serval:BIB_EDB0B234B245
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Expansion of gamma delta+ T cells in BALB/c mice infected with Leishmania major is dependent upon Th2-type CD4+ T cells.
Périodique
Infection and Immunity
Auteur(s)
Rosat J.P., Conceiçao-Silva F., Waanders G.A., Beermann F., Wilson A., Owen M.J., Hayday A.C., Huang S., Aguet M., MacDonald H.R., Louis J.A.
ISSN
0019-9567 (Print)
ISSN-L
0019-9567
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
63
Numéro
8
Pages
3000-3004
Langue
anglais
Résumé
T cells belong to either the alpha beta+ or gamma delta+ lineage as defined by their antigen receptor. Although both T-cell subsets have been shown to be involved in the immune response to the parasite Leishmania major, very little is known about possible interactions between these two populations. In this study, using a mouse model of infection with L. major, we showed that expansion of a subset of gamma delta+ T cells in vivo is dependent upon the presence of alpha beta+ CD4+ T cells. Moreover, this effect appears to be mediated via the secretion of lymphokines by CD4+ cells with a T-helper 2 (Th2) functional phenotype. Results showing that activation of Th2-type cells in mice treated with anti-immunoglobulin D antibodies or infected with Nippostrongylus brasiliensis also results in gamma delta+ T-cell expansion suggest that this effect of the Th2-type CD4+ cells is a general phenomenon not restricted to infection with L. major.
Mots-clé
Animals, CD8-Positive T-Lymphocytes/immunology, Leishmania major/immunology, Leishmaniasis, Cutaneous/immunology, Lymphocyte Activation, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Nude, Nippostrongylus/immunology, Receptors, Antigen, T-Cell, gamma-delta/immunology, Strongylida Infections/immunology, T-Lymphocyte Subsets/immunology, Th1 Cells/immunology, Th2 Cells/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 11:37
Dernière modification de la notice
20/08/2019 16:15
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