Towards multi-phase postmortem CT angiography in children: a study on a porcine model.

Détails

ID Serval
serval:BIB_ED971F0ECF1F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Towards multi-phase postmortem CT angiography in children: a study on a porcine model.
Périodique
International journal of legal medicine
Auteur(s)
Mokrane F.Z., Dercle L., Meyrignac O., Crubézy É., Rousseau H., Telmon N., Dedouit F.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
09/2018
Peer-reviewed
Oui
Volume
132
Numéro
5
Pages
1391-1403
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Multi-phase postmortem computed tomography angiography (MPMCTA) is a growing technique, which is standardized for adults. Application of this protocol for a children population is not so well defined. Our study aims to adapt the adult's protocol to children, using a porcine model.
Three groups of 18 pigs were studied, with a weight distribution between 4 and 48 kg. Different pump devices were used. Pigs of group I were studied using the Virtangio® machine, whereas pigs of groups II and III were studied using used the Medrad® machine. Study of vascular opacification was possible using a semi-quantitative method based on 26 arterial and 26 venous segments that were distributed over the entire body from the cephalic extremity to the posterior pawns.
While thoracic, abdominal, and pelvic vascular opacification were complete for each individual pig in a group, group III showed better vascular opacification for the cephalic extremity. This was also true for anterior and posterior pawns vascular opacification. Spearman correlation tests showed a significant relationship between anthropometric characteristics of pigs, injection parameters, and percentage of opacified segments. A higher percentage of opacification was obtained for individuals of lower weights, with comparatively lower quantities of contrast agent injected.
Postmortem computed tomography angiography (PMCTA) was possible for all the individuals, particularly for small weights (4 kg) using the Medrad® machine. However, further studies are needed to better understand the procedure.
Mots-clé
Animals, Autopsy, Child, Computed Tomography Angiography/instrumentation, Computed Tomography Angiography/methods, Contrast Media, Disease Models, Animal, Humans, Swine, Adults, Angiography, CT, Children, Porcine model, Postmortem
Pubmed
Web of science
Création de la notice
31/01/2018 15:06
Dernière modification de la notice
20/08/2019 17:15
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