Effect of the phenotype of the M1-middle cerebral artery occlusion on the recanalization rates in the ASTER trial.

Détails

ID Serval
serval:BIB_ED8E1C7C568D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of the phenotype of the M1-middle cerebral artery occlusion on the recanalization rates in the ASTER trial.
Périodique
Journal of neurointerventional surgery
Auteur(s)
Consoli A., Zhu F., Bourcier R., Dargazanli C., Marnat G., Duhamel A., Blanc R., Saleme S., Costalat V., Desal H., Bracard S., Labreuche J., Kyheng M., Puccinelli F., Mosimann P.J., Gory B., Piotin M., Lapergue B.
Collaborateur(s)
ASTER Trial Investigators
Contributeur(s)
Piotin M., Blanc R., Redjem H., Ciccio G., Smajda S., Mazighi M., Fahed R., Desilles J.P., Maacha M.B., Lapergue B., Rodesch G., Consoli A., Coskun O., Maria F.D., Bourdain F., Decroix J.P., Wang A., Tchkviladze M., Evrard S., Lopez D., Turjman F., Gory B., Labeyrie P.E., Riva R., Mounayer C., Saleme S., Costalat V., Bonafé A., Eker O., Gascou G., Dargazanli C., Bracard S., Tonnelet R., Derelle A.L., Anxionnat R., Desal H., Bourcier R., Daumas-Duport B., Berge J., Barreau X., Marnat G., Djemmane L., Labreuche J., Duhamel A.
ISSN
1759-8486 (Electronic)
ISSN-L
1759-8478
Statut éditorial
In Press
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Résumé
An adequate recanalization grade is an independent predictor of a good clinical outcome in patients with acute ischemic stroke. It can be obtained with stent retrievers (SR) and contact aspiration (CA). The aim of this ancillary study of the ASTER trial was to investigate the effect of the regular and irregular phenotype of the M1-middle cerebral artery (M1-MCA) segment occlusion on the procedural and clinical outcomes in the ASTER trial population.
The predetermined occlusion phenotype assessment was performed by the core laboratory of the ASTER trial and patients with M1-MCA occlusion were included in this study. Clinical and procedural outcomes were analyzed according to the technique used and to the occlusion phenotype.
188 patients were included in the analysis (95 received SR, 93 CA as first-line treatment). The occlusion phenotypes were graded as irregular in 52.7% of cases (n=99, 95% CI 45.5% to 59.8%). In patients with an irregular occlusion phenotype, complete or adequate recanalization at the end of the first-line strategy was more often achieved with SR than CA (TICI 3: SR 44.1% vs CA 22.5%, OR 0.35, 95% CI 0.14 to 0.89, p=0.027), with a shorter procedure time, a lower number of passes (>2 passes: SR 32.2% vs CA 57.5%, OR 3.31, 95% CI 1.36 to 8.03, p=0.009), and higher rates of favorable clinical outcome (SR 55.2% vs CA 31.6%, OR 0.40, 95% CI 0.16 to 0.97, p=0.042).
Irregular M1-MCA occlusion phenotypes treated with SR as first-line approach were associated with better procedural and clinical outcomes in the ASTER trial population.
Mots-clé
angiography, stent, stroke, thrombectomy
Pubmed
Création de la notice
18/07/2019 17:54
Dernière modification de la notice
21/08/2019 6:34
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