Long-term close follow-up of chorioretinal lesions in presumed ocular tuberculosis.

Details

Serval ID
serval:BIB_ED7C68A4376D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-term close follow-up of chorioretinal lesions in presumed ocular tuberculosis.
Journal
European Journal of Ophthalmology
Author(s)
Ducommun M.A., Eperon S., Khonkarly M.B., Cavassini M., Guex-Crosier Y.
ISSN
1724-6016 (Electronic)
ISSN-L
1120-6721
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
22
Number
2
Pages
195-202
Language
english
Notes
Publication types: Case Reports ; Journal Article
Abstract
PURPOSE: To evaluate the long-term outcome (up to 7 years) of presumed ocular tuberculosis (TB) when the therapeutic decision was based on WHO guidelines.
METHODS: Twelve out of 654 new uveitic patients (1998-2004) presented with choroiditis and positive tuberculosis skin test (TST) (skin lesion diameter >15 mm). Therapy was administered according to WHO recommendations after ophthalmic and systemic investigation. The area size of ocular lesions at presentation and after therapy, measured on fluorescein and indocyanine green angiographies, was considered the primary outcome. Relapse of choroiditis was considered a secondary outcome. The T-SPOT TB test was performed when it became available.
RESULTS: Visual acuity significantly improved after therapy (p=0.0357). The mean total surface of fluorescein lesions at entry was 44.8 ± 20.9 (arbitrary units) and decreased to 32.5 ± 16.9 after therapy (p=0.0165). The mean total surface of indocyanine green lesions at entry was 24.5 ± 13.3 and decreased to 10.8 ± 5.4 after therapy (p=0.0631). The T-SPOT TB revealed 2 false TST-positive results. The mean follow-up was 4.5 ± 1.5 years. Two relapses out of 10 confirmed ocular TB was observed after complete lesion healing, 2.5 years and 4.5 years after therapy, respectively.
CONCLUSIONS: A decrease of ocular lesion mean size and a mean improvement of VA were observed after antituberculous therapy. Our long-term follow-up of chorioretinal lesions demonstrated relapse of ocular tuberculosis in 10% of patients with confirmed ocular TB, despite complete initial retinal scarring.
Keywords
Adult, Aged, Antitubercular Agents/therapeutic use, Choroiditis/diagnosis, Choroiditis/drug therapy, Coloring Agents/diagnostic use, Drug Therapy, Combination, Ethambutol/therapeutic use, Female, Fluorescein Angiography, Follow-Up Studies, Humans, Indocyanine Green/diagnostic use, Interferon-gamma Release Tests, Isoniazid/therapeutic use, Male, Middle Aged, Pyrazinamide/therapeutic use, Recurrence, Rifampin/therapeutic use, Treatment Outcome, Tuberculin Test, Tuberculosis, Ocular/diagnosis, Tuberculosis, Ocular/drug therapy, Visual Acuity, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
06/07/2011 10:23
Last modification date
20/08/2019 16:15
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