Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers.

Détails

ID Serval
serval:BIB_ED64D00CF7D5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers.
Périodique
American Journal of Surgical Pathology
Auteur(s)
La Rosa S., Marando A., Furlan D., Sahnane N., Capella C.
ISSN
1532-0979 (Electronic)
ISSN-L
0147-5185
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
36
Numéro
4
Pages
601-611
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Colorectal poorly differentiated neuroendocrine carcinomas (NECs) and mixed adenoneuroendocrine carcinomas (MANECs) are well-recognized entities generally known to be associated with biological aggressiveness and poor patient survival. However, a few published papers have highlighted the existence of a subgroup of tumors with a better survival than expected; however, to date, there are no established parameters that usefully identify this category. In the present study we have investigated the morphologic features, the CpG methylator phenotype (CIMP), microsatellite instability (MSI), and the immunohistochemical profile, including the expression of transcription factors (TTF1, ASH1, CDX2, and PAX5), stem cell markers (CD117 and CD34), and cytokeratins 7 and 20, in a series of 39 carcinomas (27 NECs and 12 MANECs) to better characterize such neoplasms and to search for prognostic indicators. No different patient survival was observed between NECs and MANECs. Neoplasms showed a heterogenous spectrum of morphologic and immunohistochemical features; however, only large-cell subtype, significant peritumoral lymphoid reaction, CD117 immunoreactivity, vascular invasion, and MSI/CIMP+ status were significantly correlated with prognosis on univariable analysis. Furthermore, vascular invasion and CD117 immunoreactivity were independent prognostic markers on multivariable analysis. In addition to these prognostic features, neoplasms showed different expression of transcription factors, stem cell markers, and cytokeratins that should be considered for diagnostic purposes and, especially, for discriminating among possible differential diagnoses.
Mots-clé
Adenocarcinoma/diagnosis, Adenocarcinoma/genetics, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor/metabolism, Carcinoma, Neuroendocrine/diagnosis, Carcinoma, Neuroendocrine/genetics, Colorectal Neoplasms/diagnosis, Colorectal Neoplasms/genetics, DNA Methylation, DNA, Neoplasm/genetics, Epigenesis, Genetic, Female, Humans, Immunophenotyping, Male, Microsatellite Instability, Middle Aged, Neoplasms, Multiple Primary, Prognosis, Proto-Oncogene Proteins c-kit/metabolism, Real-Time Polymerase Chain Reaction, Survival Rate
Pubmed
Web of science
Création de la notice
06/09/2016 13:09
Dernière modification de la notice
20/08/2019 16:15
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