Adoptive transfer of viable motheaten (mev) humoral autoimmunity: IgM to IgG switch of the hyperglobulinaemia in nude, beige recipient mice

Details

Serval ID
serval:BIB_ED0B15F37A6C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Adoptive transfer of viable motheaten (mev) humoral autoimmunity: IgM to IgG switch of the hyperglobulinaemia in nude, beige recipient mice
Journal
Immunology
Author(s)
Kuntz  L., Pflumio  F., Velin  D., Loor  F.
ISSN
0019-2805 (Print)
Publication state
Published
Issued date
11/1990
Volume
71
Number
3
Pages
341-6
Notes
Journal Article --- Old month value: Nov
Abstract
Homozygous C57BL/6 nude, beige mice (B6 nu,bg) were used as recipients for the transfer of lymphoid cells from autoimmune homozygous B6 'viable motheaten' mice (B6 mev) and from either normal B6 mice (B6 wild) or B6 bg mice as controls. Surprisingly, the mev cell grafts prolonged survival of these short-living doubly immunodeficient recipients. Although the [mev----nu,bg] chimeras did not develop the mev external necrosis phenotype, they showed a hyperglobulinaemia and a significant increase of their anti-single-stranded DNA (ssDNA) antibody titres, compared to control chimeras ([bg----nu,bg] and [wild----nu,bg]). However, this hyperglobulinaemia was quite different from the mev-type hyperglobulinaemia, with poor contribution of the IgM isotype. Moreover, the anti-ssDNA antibodies were more distributed among the various Ig classes than the anti-ssDNA antibodies of the mev homozygous mice. Though the adoptive transfer of some mev-type humoral autoimmunity symptoms were achieved in this chimera model, the recipient mice did not suffer from the several other features of the mev syndrom, such as the severe pathology and the extremely high IgM serological levels.
Keywords
Animals Antibodies, Antinuclear/analysis Autoantibodies/analysis *Autoimmunity Chimera DNA, Single-Stranded/immunology Hypergammaglobulinemia/*immunology *Immunization, Passive Immunoglobulin G/*analysis Immunoglobulin M/*analysis Immunoglobulins/analysis Mice Mice, Inbred C57BL Mice, Nude
Pubmed
Web of science
Create date
25/01/2008 17:10
Last modification date
20/08/2019 17:14
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