Nonoccupational HIV post-exposure prophylaxis: a 10-year retrospective analysis.

Details

Serval ID
serval:BIB_ECDF25754A57
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nonoccupational HIV post-exposure prophylaxis: a 10-year retrospective analysis.
Journal
HIV Medicine
Author(s)
Tissot F., Erard V., Dang T., Cavassini M.
ISSN
1468-1293[electronic], 1464-2662[linking]
Publication state
Published
Issued date
2010
Volume
11
Number
9
Pages
584-592
Language
english
Abstract
BACKGROUND: We conducted a retrospective analysis of administration of nonoccupational HIV post-exposure prophylaxis (nPEP) in a single centre where tracing and testing of the source of exposure were carried out systematically over a 10-year period.
METHODS: Files of all nPEP requests between 1998 and 2007 were reviewed. Characteristics of the exposed and source patients, the type of exposure, and clinical and serological outcomes were analysed.
RESULTS: nPEP requests increased by 850% over 10 years. Among 910 events, 58% were heterosexual exposures, 15% homosexual exposures, 6% sexual assaults and 20% nonsexual exposures. In 208 events (23%), the source was reported to be HIV positive. In the remaining cases, active source tracing enabled 298 HIV tests to be performed (42%) and identified 11 HIV infections (3.7%). nPEP was able to be avoided or interrupted in 31% of 910 events when the source tested negative. Of 710 patients who started nPEP, 396 (56%) reported side effects, among whom 39 (5%) had to interrupt treatment. There were two HIV seroconversions, and neither was attributed to nPEP failure.
CONCLUSIONS: nPEP requests increased over time. HIV testing of the source person avoided nPEP in 31% of events and was therefore paramount in the management of potential HIV exposures. Furthermore, it allowed active screening of populations potentially at risk for undiagnosed HIV infection, as shown by the increased HIV prevalence in these groups (3.7%) compared with a prevalence of 0.3% in Switzerland as a whole.
Keywords
community, HIV, nonoccupational, out-patient, post-exposure prophylaxis, human-immunodeficiency-virus, injection-drug use, sexual assault, zidovudine treatment, use exposure, viral load, infection, seroconversion, transmission, people
Pubmed
Web of science
Create date
29/09/2010 15:29
Last modification date
20/08/2019 16:14
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