Impact of Clinical and Pharmacological Parameters on Faecal Microbiota Transplantation Outcome in Clostridioides difficile Infections: Results of a 5-Year French National Survey.
Details
Serval ID
serval:BIB_ECC7BB2F1015
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of Clinical and Pharmacological Parameters on Faecal Microbiota Transplantation Outcome in Clostridioides difficile Infections: Results of a 5-Year French National Survey.
Journal
Alimentary pharmacology & therapeutics
Working group(s)
French Faecal Transplant Group (GFTF)
Contributor(s)
Benech N., Cassir N., Alric L., Melchior C., Mosca A., Joly A.C., Kapel N., Barbut F., Galperine T., Pigneur B., Davido B., Schneider S., Briot T., Wasiak M., Nebad B., Batista R., Mosca A., Bleibtreu A., Scanzi J., Sokol H., Sintes R., Corriger A., Flet L., Batista R., Perlemuter G., Ahloulay M., Sadou Yaye H., de Rougemont A., Olivier E., Burucoa C., Gobert J.G., Landman C., Vignal L., Joly F., Ravinet A., Bellanger A., Sabate J.M., Humbert C., Aron J., Charpentier C., Moreno-Sabater A., Takoudju C., Poirier P., Tanne F., Dor V., Stampfli C.
ISSN
1365-2036 (Electronic)
ISSN-L
0269-2813
Publication state
In Press
Peer-reviewed
Oui
Editor
Benech N Cassir N. Alric L. Melchior C. Mosca A. Joly A. C. Kapel N. Barbut F. Galperine T. Pigneur B. Davido B. Schneider S. Briot T. Wasiak M. Nebad B. Batista R. Mosca A. Bleibtreu A. Scanzi J. Sokol H. Sintes R. Corriger A. Flet L. Batista R. Perlemuter G. Ahloulay M. Sadou Yaye H. de Rougemont A. Olivier E. Burucoa C. Gobert J. G. Landman C. Vignal L. Joly F. Ravinet A. Bellanger A. Sabate J. M. Humbert C. Aron J. Charpentier C. Moreno-Sabater A. Takoudju C. Poirier P. Tanne F. Dor V. Stampfli C., French Faecal Transplant Group
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Publication Status: aheadofprint
Abstract
Detailed comparative assessment of procedure-related factors associated with faecal microbiota transplantation (FMT) efficacy in Clostridioides difficile infection (CDI) is limited.
We took advantage of the differences in procedures at the various French FMT centres to determine clinical and procedure-related factors associated with FMT success in CDI.
We performed a nationwide retrospective multicentre cohort study. All FMTs performed within The French Faecal Transplant Group for CDI from 2018 to 2022 were included. Clinical data were collected retrospectively from recipient medical files, characteristics of stool transplant preparations were prospectively collected by each Pharmacy involved. Univariate and multivariate analyses were performed using Fisher's test and multiple logistic regression.
Six hundred fifty-eight FMTs were performed for 617 patients in 17 centres. The overall efficacy of FMT was 84.3% (520/617), with 0.5% of severe adverse events possibly related to FMT (3/658). Forty-seven patients were treated at the first recurrence of CDI with a similar success rate (85.1%). Severe chronic kidney disease (CKD; OR: 2.18, 95%CI [1.20-3.88]), non-severe refractory CDI (OR: 15.35, [1.94-318.2]), the use of ≥ 80% glycerol (OR: 2.52, [1.11-5.67]), insufficient bowel cleansing (OR: 5.47, [1.57-20.03]) and partial FMT retention (OR: 9.97, [2.62-48.49]) were associated with CDI recurrence within 8 weeks.
Conditions of transplant manufacturing, bowel cleansing, and a route of delivery tailored to the patient's characteristics are key factors in optimising FMT efficacy. FMT at first recurrence showed high success in real-life practice, whereas it had lower efficacy in severe CDI and non-severe refractory CDI.
We took advantage of the differences in procedures at the various French FMT centres to determine clinical and procedure-related factors associated with FMT success in CDI.
We performed a nationwide retrospective multicentre cohort study. All FMTs performed within The French Faecal Transplant Group for CDI from 2018 to 2022 were included. Clinical data were collected retrospectively from recipient medical files, characteristics of stool transplant preparations were prospectively collected by each Pharmacy involved. Univariate and multivariate analyses were performed using Fisher's test and multiple logistic regression.
Six hundred fifty-eight FMTs were performed for 617 patients in 17 centres. The overall efficacy of FMT was 84.3% (520/617), with 0.5% of severe adverse events possibly related to FMT (3/658). Forty-seven patients were treated at the first recurrence of CDI with a similar success rate (85.1%). Severe chronic kidney disease (CKD; OR: 2.18, 95%CI [1.20-3.88]), non-severe refractory CDI (OR: 15.35, [1.94-318.2]), the use of ≥ 80% glycerol (OR: 2.52, [1.11-5.67]), insufficient bowel cleansing (OR: 5.47, [1.57-20.03]) and partial FMT retention (OR: 9.97, [2.62-48.49]) were associated with CDI recurrence within 8 weeks.
Conditions of transplant manufacturing, bowel cleansing, and a route of delivery tailored to the patient's characteristics are key factors in optimising FMT efficacy. FMT at first recurrence showed high success in real-life practice, whereas it had lower efficacy in severe CDI and non-severe refractory CDI.
Keywords
Clostridioides difficile infection, faecal microbiota transplantation, frozen preparation, glycerol
Pubmed
Open Access
Yes
Create date
25/10/2024 14:12
Last modification date
26/10/2024 6:12
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