Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network.

Détails

ID Serval
serval:BIB_ECC2D5987BCD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Titre
Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network.
Périodique
Cell Research
Auteur(s)
Chen K.W., Boucher D., Broz P.
ISSN
1748-7838 (Electronic)
ISSN-L
1001-0602
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
29
Numéro
3
Pages
181-182
Langue
anglais
Résumé
he NLRP3 inflammasome detects a variety of pathogen-derived and host-derived signals, but its mechanism of activation has long remained uncharacterized. In a recent study in Nature, Chen et al. demonstrate that NLRP3 activators induce the disassembly of the trans-Golgi network (TGN) and that NLRP3 is targeted for activation at the dispersed TGN (dTGN) by ionic bonding between its conserved polybasic region and phosphatidylinositol-4-phosphates on the dTGN.
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/02/2019 11:08
Dernière modification de la notice
20/08/2019 17:14
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