A qualitative continuous model of cellular auxin and brassinosteroid signaling and their crosstalk.

Détails

Ressource 1Télécharger: serval:BIB_EC715645E193.P001 (987.68 [Ko])
Etat: Public
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ID Serval
serval:BIB_EC715645E193
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A qualitative continuous model of cellular auxin and brassinosteroid signaling and their crosstalk.
Périodique
Bioinformatics
Auteur(s)
Sankar M., Osmont K.S., Rolcik J., Gujas B., Tarkowska D., Strnad M., Xenarios I., Hardtke C.S.
ISSN
1367-4811 (Electronic)
ISSN-L
1367-4803
Statut éditorial
Publié
Date de publication
2011
Volume
27
Numéro
10
Pages
1404-1412
Langue
anglais
Résumé
Motivation: Hormone pathway interactions are crucial in shaping plant development, such as synergism between the auxin and brassinosteroid pathways in cell elongation. Both hormone pathways have been characterized in detail, revealing several feedback loops. The complexity of this network, combined with a shortage of kinetic data, renders its quantitative analysis virtually impossible at present.Results: As a first step towards overcoming these obstacles, we analyzed the network using a Boolean logic approach to build models of auxin and brassinosteroid signaling, and their interaction. To compare these discrete dynamic models across conditions, we transformed them into qualitative continuous systems, which predict network component states more accurately and can accommodate kinetic data as they become available. To this end, we developed an extension for the SQUAD software, allowing semi-quantitative analysis of network states. Contrasting the developmental output depending on cell type-specific modulators enabled us to identify a most parsimonious model, which explains initially paradoxical mutant phenotypes and revealed a novel physiological feature.
Mots-clé
Arabidopsis/metabolism, Cell Growth Processes, Indoleacetic Acids/metabolism, Models, Biological, Plant Growth Regulators/metabolism, Signal Transduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/02/2012 15:31
Dernière modification de la notice
25/09/2019 6:11
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