Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study.

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Serval ID
serval:BIB_EC5AC86EB992
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study.
Journal
Journal of child psychology and psychiatry, and allied disciplines
Author(s)
Rudaz D., Vandeleur C.L., Gholam M., Castelao E., Strippoli M.F., Marquet P., Aubry J.M., Merikangas K.R., Preisig M.
ISSN
1469-7610 (Electronic)
ISSN-L
0021-9630
Publication state
Published
Issued date
04/2021
Peer-reviewed
Oui
Volume
62
Number
4
Pages
404-413
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
There is still limited evidence from prospective high-risk research on the evolution of specific disorders that may emerge early in the development of mood disorders. Moreover, few studies have examined the specificity of mood disorder subtypes among offspring of parents with both major subtypes of mood disorders and controls based on prospective tracking across the transition from childhood to adulthood. Our specific objectives were to (a) identify differences in patterns of psychopathological precursors among youth with (hypo)mania compared to MDD and (b) examine whether these patterns differ by subtypes of parental mood disorders.
Our data stem from a prospective cohort study of 449 directly interviewed offspring (51% female, mean age 10.1 years at study intake) of 88 patients with BPD, 71 with MDD, 30 with substance use disorders and 60 medical controls. The mean duration of follow-up was 13.2 years with evaluations conducted every three years.
Within the whole cohort of offspring, MDE (Hazard Ratio = 4.44; 95%CI: 2.19-9.02), CD (HR = 3.31;1.55-7.07) and DUD (HR = 2.54; 1.15-5.59) predicted the onset of (hypo)manic episodes, whereas MDD in offspring was predicted by SAD (HR = 1.53; 1.09-2.15), generalized anxiety (HR = 2.56; 1.05-6.24), and panic disorder (HR = 3.13; 1.06-9.23). The early predictors of (hypo)mania in the whole cohort were also significantly associated with the onset of (hypo)mania among the offspring of parents with BPD.
The onset of mood disorders is frequently preceded by identifiable depressive episodes and nonmood disorders. These precursors differed by mood subtype in offspring. High-risk offspring with these precursors should be closely monitored to prevent the further development of MDD or conversion to BPD.
Keywords
Mood disorders, anxiety disorders, drug misuse, offspring of bipolar parents, offspring of depressed parents, precursors
Pubmed
Web of science
Create date
02/09/2020 9:51
Last modification date
21/07/2022 5:35
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