MC1R variants affect the expression of melanocortin and melanogenic genes and the association between melanocortin genes and coloration.

Détails

ID Serval
serval:BIB_EC5595BB1921
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MC1R variants affect the expression of melanocortin and melanogenic genes and the association between melanocortin genes and coloration.
Périodique
Molecular ecology
Auteur(s)
San-Jose L.M., Ducrest A.L., Ducret V., Simon C., Richter H., Wakamatsu K., Roulin A.
ISSN
1365-294X (Electronic)
ISSN-L
0962-1083
Statut éditorial
Publié
Date de publication
01/2017
Peer-reviewed
Oui
Volume
26
Numéro
1
Pages
259-276
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The melanocortin-1 receptor (MC1R) gene influences coloration by altering the expression of genes acting downstream in the melanin synthesis. MC1R belongs to the melanocortin system, a genetic network coding for the ligands that regulate MC1R and other melanocortin receptors controlling different physiological and behavioural traits. The impact of MC1R variants on these regulatory melanocortin genes was never considered, even though MC1R mutations could alter the influence of these genes on coloration (e.g. by decreasing MC1R response to melanocortin ligands). Using barn owl growing feathers, we investigated the differences between MC1R genotypes in the (co)expression of six melanocortin and nine melanogenic-related genes and in the association between melanocortin gene expression and phenotype (feather pheomelanin content). Compared to the MC1R rufous allele, responsible for reddish coloration, the white allele was not only associated with an expected lower expression of melanogenic-related genes (TYR, TYRP1, OCA2, SLC45A2, KIT, DCT) but also with a lower MC1R expression and a higher expression of ASIP, the MC1R antagonist. More importantly, the expression of PCSK2, responsible for the maturation of the MC1R agonist, α-melanocyte-stimulating hormone, was positively related to pheomelanin content in MC1R white homozygotes but not in individuals carrying the MC1R rufous allele. These findings indicate that MC1R mutations not only alter the expression of melanogenic-related genes but also the association between coloration and the expression of melanocortin genes upstream of MC1R. This suggests that MC1R mutations can modulate the regulation of coloration by the pleiotropic melanocortin genes, potentially decoupling the often-observed associations between coloration and other phenotypes.

Mots-clé
Alleles, Animals, Feathers, Gene Regulatory Networks, Genotype, Melanocortins/genetics, Pigmentation/genetics, Receptor, Melanocortin, Type 1/genetics, Strigiformes/genetics, barn owl, colour genetics, colour polymorphism, gene expression, melanin, pleiotropy
Pubmed
Web of science
Création de la notice
29/09/2016 18:49
Dernière modification de la notice
20/08/2019 17:14
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