Predictive Factors and Risk Model for Positive Circumferential Resection Margin Rate After Transanal Total Mesorectal Excision in 2653 Patients With Rectal Cancer.
Details
Serval ID
serval:BIB_EBEC63CEB78F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Predictive Factors and Risk Model for Positive Circumferential Resection Margin Rate After Transanal Total Mesorectal Excision in 2653 Patients With Rectal Cancer.
Journal
Annals of surgery
Working group(s)
International TaTME Registry Collaborative
Contributor(s)
Adamina M., Aigner F., Al Furajii H., Albers B., Allison A.S., Arezzo A., Arnold S.J., Aryal K., Atallah S., Austin R., Baig M.K., Baloyiannis I., Bandyopadhyay D., Banerjee S., Banky B., Baral J., Belgers E., Bell S., Berti S., Biebl M., Bloemendaal B., Boni L., Bordeianou L., Borreca D., Bosker RJI, Box B., Boyce S., Bravo R., van den Broeck S., Brown C., Bruegger L., Brunner W., Buchli C., Buchs N.C., Buia A., Burt C., Cahill R., Campana J.P., Campbell K., Di Candido F., Capolupo G.T., Caricato M., Caro-Tarrago A., Cassinotti E., Caycedo A., Chandrasinghe P., Chaudhri S., Chernyshov S., Chitsabesan P., Christoforidis D., Clark D.A., Coget J., Courtney E.D., Cunningham C., D'Hooge P., D'Hoore A., Dagbert F., Dalton S.J., Dapri G., Dawson R., Dayal S., Delgado S., Delrio P., Doerner J., Doornebosch P., Duff S., Dzhumabaev K.E., Edwards T., Egenvall M., Eriksen J.R., Espin E., Estevez-Schwarz L., Faes S., Fearden A., Feleppa C., Forgan T., Forsmo H., Francis N.K., Frontali A., Fu C., Gamage B., Garcia JIR, Geissmann D., van Geluwe B., Gill K., Glockler M., Gloor S., Gomez C.J., de Graaf E., Grolich T., Guido J., Hahnloser D., Hance J., Harikrishnan A., Haunold I., Hayes J., Hendrickx T., Heriot A., Hoffmann T.J., HongWei Y., Huang J., James H., Ial R., Ito M., Janssens M., Joy H., Juliao GPS, Karimuddin A., Katory M., Killeen S., Kneist W., Knol J., Komen N., Kukreja N., Kusters M., de Lacy A., Lakatos L., Lambrechts A., Laso C.A., Leao P., Lezoche E., Liberman S.A., Lidder P., Lima M.A., Lorenzon L., Mackey P., Maggiori L., Mamedli Z.Z., Mansfield S., Marcoen S., Marcy T., Maroon T., Marta Pascual D., Marti L., Maslekar S., McCallum I., McCarthy K., Mendes CRS, Merrie A., Michalopoulos A., Mikalauskas S., Miles AWF, Mills S.C., Miroshnychenko Y., Mittermair C., Molloy R., Montroni I., Moore E., Moore T., Mooslechner B., Morino M., Moslein G., Muratore A., Mutafchiyski V.M., Myers A., Nicol D., van Nieuwenhove Y., Nishizaki D., Nolan G.J., Ochsner A., Oh J.H., Ormazabal P.C., Otero A., Ouro S., Panis Y., Papavramidis T., von Papen M., Paraoan M., Pastor C., Pastor E., Penchev D., Pera M., Perdawood S.K., Perez R.O., Persiani R., Pfeffer F., Phang P.T., Pichetto A., Pirenne Y., Pockney P., de Pooter K., Poskus E., Pros I., Rajendran N., Raval M.J., Rega D., Ricciardi R., van Riel W., Ris F., Riss S., Rockall T.A., Romagnolo L., Romero-Marcos J.M., Roquete P., Rossi G., Ruiz M.G., Rybakov E., Sakai Y., Scala A., Scheiding M.M., Monica Millan G., Seva-Pereira G., Sguinzi R., Shaikh I.A., Shalaby M., Sharma A., Sietses C., Sileri P., Simo V., Singh B., Slesser A., Sohn D.K., Sosef M., Soravia C., Speakman C., Spinelli A., van Sprundel F., van Steenkiste F., Stevenson ARL, Stift A., Storms P., Studer P., Talsma A.K., Tanis P.J., Tejedor P., la Terra A., Torkington J., Toscano M.J., Tschann P., Tuech J.J., Tuynman J., Tzovaras G., Ugolini G., Vallribera F., Vanrykel F., Vorburger S., Warner M., Warren O.J., Warrier S., Warusavitarne J., Wegstapel H., Weiss H., Witzig J.A., Wolff T., Wolthuis A., Wu L., Wynn G., Zhongtao Z., Zingg U., Ziyaie D.
ISSN
1528-1140 (Electronic)
ISSN-L
0003-4932
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
270
Number
5
Pages
884-891
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The aim of this study was to determine the incidence of, and preoperative risk factors for, positive circumferential resection margin (CRM) after transanal total mesorectal excision (TaTME).
TaTME has the potential to further reduce the rate of positive CRM for patients with low rectal cancer, thereby improving oncological outcome.
A prospective registry-based study including all cases recorded on the international TaTME registry between July 2014 and January 2018 was performed. Endpoints were the incidence of, and predictive factors for, positive CRM. Univariate and multivariate logistic regressions were performed, and factors for positive CRM were then assessed by formulating a predictive model.
In total, 2653 patients undergoing TaTME for rectal cancer were included. The incidence of positive CRM was 107 (4.0%). In multivariate logistic regression analysis, a positive CRM after TaTME was significantly associated with tumors located up to 1 cm from the anorectal junction, anterior tumors, cT4 tumors, extra-mural venous invasion (EMVI), and threatened or involved CRM on baseline MRI (odds ratios 2.09, 1.66, 1.93, 1.94, and 1.72, respectively). The predictive model showed adequate discrimination (area under the receiver-operating characteristic curve >0.70), and predicted a 28% risk of positive CRM if all risk factors were present.
Five preoperative tumor-related characteristics had an adverse effect on CRM involvement after TaTME. The predicted risk of positive CRM after TaTME for a specific patient can be calculated preoperatively with the proposed model and may help guide patient selection for optimal treatment and enhance a tailored treatment approach to further optimize oncological outcomes.
TaTME has the potential to further reduce the rate of positive CRM for patients with low rectal cancer, thereby improving oncological outcome.
A prospective registry-based study including all cases recorded on the international TaTME registry between July 2014 and January 2018 was performed. Endpoints were the incidence of, and predictive factors for, positive CRM. Univariate and multivariate logistic regressions were performed, and factors for positive CRM were then assessed by formulating a predictive model.
In total, 2653 patients undergoing TaTME for rectal cancer were included. The incidence of positive CRM was 107 (4.0%). In multivariate logistic regression analysis, a positive CRM after TaTME was significantly associated with tumors located up to 1 cm from the anorectal junction, anterior tumors, cT4 tumors, extra-mural venous invasion (EMVI), and threatened or involved CRM on baseline MRI (odds ratios 2.09, 1.66, 1.93, 1.94, and 1.72, respectively). The predictive model showed adequate discrimination (area under the receiver-operating characteristic curve >0.70), and predicted a 28% risk of positive CRM if all risk factors were present.
Five preoperative tumor-related characteristics had an adverse effect on CRM involvement after TaTME. The predicted risk of positive CRM after TaTME for a specific patient can be calculated preoperatively with the proposed model and may help guide patient selection for optimal treatment and enhance a tailored treatment approach to further optimize oncological outcomes.
Keywords
Adenocarcinoma/mortality, Adenocarcinoma/pathology, Adenocarcinoma/surgery, Aged, Cohort Studies, Disease-Free Survival, Endoscopic Mucosal Resection/methods, Endoscopic Mucosal Resection/mortality, Female, Follow-Up Studies, Humans, Length of Stay, Logistic Models, Male, Margins of Excision, Middle Aged, Multivariate Analysis, Operative Time, Predictive Value of Tests, Proctectomy/methods, Prognosis, Prospective Studies, Rectal Neoplasms/mortality, Rectal Neoplasms/pathology, Rectal Neoplasms/surgery, Registries, Risk Assessment, Survival Analysis, Transanal Endoscopic Surgery/methods, Transanal Endoscopic Surgery/mortality, Treatment Outcome
Pubmed
Web of science
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16/07/2021 11:01
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27/09/2023 5:58
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