A genome-wide association study of anorexia nervosa.

Details

Ressource 1Download: BIB_EBE853EF2EB7.P001.pdf (551.82 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_EBE853EF2EB7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A genome-wide association study of anorexia nervosa.
Journal
Molecular Psychiatry
Author(s)
Boraska V., Franklin C.S., Floyd J.A., Thornton L.M., Huckins L.M., Southam L., Rayner N.W., Tachmazidou I., Klump K.L., Treasure J., Lewis C.M., Schmidt U., Tozzi F., Kiezebrink K., Hebebrand J., Gorwood P., Adan R.A., Kas M.J., Favaro A., Santonastaso P., Fernández-Aranda F., Gratacos M., Rybakowski F., Dmitrzak-Weglarz M., Kaprio J., Keski-Rahkonen A., Raevuori A., Van Furth E.F., Slof-Op 't Landt M.C., Hudson J.I., Reichborn-Kjennerud T., Knudsen G.P., Monteleone P., Kaplan A.S., Karwautz A., Hakonarson H., Berrettini W.H., Guo Y., Li D., Schork N.J., Komaki G., Ando T., Inoko H., Esko T., Fischer K., Männik K., Metspalu A., Baker J.H., Cone R.D., Dackor J., DeSocio J.E., Hilliard C.E., O'Toole J.K., Pantel J., Szatkiewicz J.P., Taico C., Zerwas S., Trace S.E., Davis O.S., Helder S., Bühren K., Burghardt R., de Zwaan M., Egberts K., Ehrlich S., Herpertz-Dahlmann B., Herzog W., Imgart H., Scherag A., Scherag S., Zipfel S., Boni C., Ramoz N., Versini A., Brandys M.K., Danner U.N., de Kovel C., Hendriks J., Koeleman B.P., Ophoff R.A., Strengman E., van Elburg A.A., Bruson A., Clementi M., Degortes D., Forzan M., Tenconi E., Docampo E., Escaramís G., Jiménez-Murcia S., Lissowska J., Rajewski A., Szeszenia-Dabrowska N., Slopien A., Hauser J., Karhunen L., Meulenbelt I., Slagboom P.E., Tortorella A., Maj M., Dedoussis G., Dikeos D., Gonidakis F., Tziouvas K., Tsitsika A., Papezova H., Slachtova L., Kennedy J.L., Levitan R.D., Yilmaz Z., Huemer J., Koubek D., Merl E., Wagner G., Lichtenstein P., Breen G., Cohen-Woods S., Farmer A., McGuffin P., Cichon S., Giegling I., Herms S., Rujescu D., Schreiber S., Wichmann H.E., Dina C., Sladek R., Gambaro G., Soranzo N., Julia A., Marsal S., Rabionet R., Gaborieau V., Dick D.M., Palotie A., Ripatti S., Widén E., Andreassen O.A., Espeseth T., Lundervold A., Reinvang I., Steen V.M., Le Hellard S., Mattingsdal M., Ntalla I., Bencko V., Foretova L., Janout V., Navratilova M., Gallinger S., Pinto D., Scherer S.W., Aschauer H., Carlberg L., Schosser A., Alfredsson L., Ding B., Klareskog L., Padyukov L., Courtet P., Guillaume S., Jaussent I., Finan C., Kalsi G., Roberts M., Logan D.W., Peltonen L., Ritchie G.R., Barrett J.C., Estivill X., Estivill X., Hinney A., Sullivan P.F., Collier D.A., Zeggini E., Bulik C.M.
Working group(s)
Martaskova D., Wellcome Trust Case Control Consortium 3
Contributor(s)
Anderson CA., Barrett JC., Floyd JA., Franklin CS., McGinnis R., Soranzo N., Zeggini E., Sambrook J., Stephens J., Ouwehand WH., McArdle WL., Ring SM., Strachan DP., Alexander G., Bulik CM., Collier DA., Conlon PJ., Dominiczak A., Duncanson A., Hill A., Langford C., Lord G., Maxwell AP., Morgan L., Peltonen L., Sandford RN., Sheerin N., Soranzo N., Vannberg FO., Barrett JC., Blackburn H., Chen WM., Edkins S., Gillman M., Gray E., Hunt SE., Langford C., Onengut-Gumuscu S., Potter S., Rich SS., Simpkin D., Whittaker P.
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
19
Number
10
Pages
1085-1094
Language
english
Abstract
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.
Pubmed
Web of science
Create date
02/12/2014 17:48
Last modification date
20/08/2019 16:14
Usage data